Photodimerization in pyrimidine-substituted dipeptides

Brian Lohse, P.S. Ramanujam, Søren Hvilsted, Rolf Henrik Berg

Research output: Contribution to journalJournal articleResearchpeer-review


Ten N-epsilon-glycylornithineamide derivatives have been synthesized containing various N-alpha-linked pyrimidine-1-ylacetyl groups which can undergo (2 pi + 2 pi) photodimerization on irradiation with UV light at 254 rim. The dimerization efficiency of the free and bound pyrimidine groups was compared in aqueous solution: it was dependent on the substitution of the pyrimidine ring. N-alpha,N-alpha'-bis-(uracil-1-ylacetyl)-(N-epsilon-glycylomithineamide) and N-alpha,N-alpha'-bis-(5-bromouracil-1-ylacetyl)-(N-epsilon-glycylomithineamide) were identified as possible candidates for optical data storage.
Original languageEnglish
JournalJournal of Peptide Science
Issue number8
Pages (from-to)499-505
Publication statusPublished - 2005


  • Pyrimidine
  • Photodimerization
  • Cycloaddition
  • Dipeptide

Fingerprint Dive into the research topics of 'Photodimerization in pyrimidine-substituted dipeptides'. Together they form a unique fingerprint.

Cite this