Petasis Three-Component Coupling Reactions of Hydrazides for the Synthesis of Oxadiazolones and Oxazolidinones

Sebastian Thordal Le Quement, Thomas Flagstad, Remi Jacob Thomsen Mikkelsen, Mette Reimert Hansen, Michael C. Givskov, Thomas Eiland Nielsen

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Abstract

An application of readily available hydrazides in the Petasis 3-component coupling reaction is presented. An investigation of the substrate scope was performed to establish a general, synthetically useful protocol for the formation of hydrazido alcohols, which were selectively converted to oxazolidinone and oxadiazolone ring systems through triphosgene-mediated cyclization reactions.
Original languageEnglish
JournalOrganic Letters
Volume14
Issue number2
Pages (from-to)640-643
ISSN1523-7060
DOIs
Publication statusPublished - 2012

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