PET in vivo generators 134Ce and 140Nd on an internalizing monoclonal antibody probe

G. W. Severin*, J. Fonslet, L. K. Kristensen, C. H. Nielsen, A. I. Jensen, A. Kjær, A. P. Mazar, K. Johnston, U. Köster

*Corresponding author for this work

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Abstract

The in vivo-generator radionuclides 140Nd (t1/2 = 3.4 d) and 134Ce (t1/2 = 3.2 d) were used to trace a urokinase-type plasminogen activator (uPA)-targeting mouse monoclonal antibody, ATN-291, in U87 MG xenograft tumor-bearing mice. ATN-291 is known to internalize on the uPA/uPA-receptor pair, making it an appropriate targeting vector for investigating the fate of in vivo generator daughters on internalizing probes. Ante-mortem and post-mortem PET imaging at 120 h post-injection gave no indication of redistribution of the positron emitting daughter nuclides 134La and 140Pr from tumor tissue (p > 0.5). The lack of redistribution indicates that the parent radionuclides 134Ce and 140Nd could be considered as long-lived PET-diagnostic matches to therapeutic radionuclides like 177Lu, 161Tb and 225Ac when internalizing bioconjugates are employed.
Original languageEnglish
Article number3863
JournalScientific Reports
Volume12
Number of pages7
ISSN2045-2322
DOIs
Publication statusPublished - 2022

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