@inbook{fb557e3ff79242f5be089c857bed20c7,
title = "Perspective on PSE in pharmaceutical process development and innovation",
abstract = "Development and possible uses of a systematic methodology for pharmaceutical process development based on enhanced process understanding, a data-rich environment, and exploiting opportunities for continuous operation is presented in this chapter. The methodology is implemented into a computer-aided framework through which systematic model-based methods and tools are retrieved and used for specific pharmaceutical process-related problems. For this purpose, a suite of computer-aided methods and tools needed to generate process knowledge and to evaluate different operational scenarios have been developed. These include a special reactions database, a modeling tool plus a model library, a solvent-swap tool, solid solubility prediction tool, simulation engine, and many more. A case study involving the production of ibuprofen is used to illustrate the need and use of the developed and implemented methods and tools, highlighting the contributions of process systems engineering in pharmaceutical process development.",
author = "Emmanouil Papadakis and Woodley, {John M.} and Rafiqul Gani",
year = "2018",
doi = "10.1016/B978-0-444-63963-9.00024-5",
language = "English",
volume = "41",
series = "Computer Aided Chemical Engineering",
publisher = "Elsevier",
pages = "597--656",
editor = "Singh, {Ravendra } and Yuan, {Zhihong }",
booktitle = "Process Systems Engineering for Pharmaceutical Manufacturing",
address = "United Kingdom",
}