Persistent developmental toxicity in rat offspring after low dose exposure to a mixture of endocrine disrupting pesticides

Pernille Rosenskjold Jacobsen, Marta Axelstad Petersen, Julie Boberg, Louise Krag Isling, Sofie Christiansen, Karen Riiber Mandrup, Line Olrik Berthelsen, Anne Marie Vinggaard, Ulla Hass

Research output: Contribution to journalConference articleResearchpeer-review


There is growing concern of permanent damage to the endocrine and nervous systems after developmental exposure to endocrine disrupting chemicals. In this study the permanent reproductive and neurobehavioral effects of combined exposure to five endocrine disrupting pesticides, epoxiconazole, mancozeb, prochloraz, tebuconazole and procymidone, were examined. Pregnant and lactating rat dams were dosed with a mixture of the five pesticides at three different doses, or with the individual pesticides at one of two doses.Adverse effects were observed in young and adult male offspring from the group exposed to the highest dose of the mixture. These included reduced prostate and epididymis weights, increased testes weights, altered prostate histopathology, increased density of mammary glands, reduced sperm counts, and decreased spatial learning. As no significant effects were seen following single compound exposure at the doses included in the highest mixture dose, these results indicate cumulative adverse effects of the pesticide mixture.
Original languageEnglish
JournalReproductive Toxicology
Issue number2
Pages (from-to)237-250
Publication statusPublished - 2012
Event40th European Teratology Society Conference - Linz, Austria
Duration: 2 Sept 20125 Sept 2012
Conference number: 40


Conference40th European Teratology Society Conference
Internet address


  • Mixture
  • Developmental toxicology
  • Male Wistar rat
  • Female Wistar rat
  • Endocrine disrupter
  • Pesticides
  • Mammary gland
  • Whole mount
  • Reproductive organs
  • Behavior
  • Estrous
  • Estrus
  • Steroid hormones
  • Sperm count
  • Thyroidea
  • Antiandrogen


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