Persistent developmental toxicity in rat offspring after low dose exposure to a mixture of endocrine disrupting pesticides

Pernille Rosenskjold Jacobsen, Marta Axelstad Petersen, Julie Boberg, Louise Krag Isling, Sofie Christiansen, Karen Riiber Mandrup, Line Olrik Berthelsen, Anne Marie Vinggaard, Ulla Hass

Research output: Contribution to journalConference articleResearchpeer-review

Abstract

There is growing concern of permanent damage to the endocrine and nervous systems after developmental exposure to endocrine disrupting chemicals. In this study the permanent reproductive and neurobehavioral effects of combined exposure to five endocrine disrupting pesticides, epoxiconazole, mancozeb, prochloraz, tebuconazole and procymidone, were examined. Pregnant and lactating rat dams were dosed with a mixture of the five pesticides at three different doses, or with the individual pesticides at one of two doses.Adverse effects were observed in young and adult male offspring from the group exposed to the highest dose of the mixture. These included reduced prostate and epididymis weights, increased testes weights, altered prostate histopathology, increased density of mammary glands, reduced sperm counts, and decreased spatial learning. As no significant effects were seen following single compound exposure at the doses included in the highest mixture dose, these results indicate cumulative adverse effects of the pesticide mixture.
Original languageEnglish
JournalReproductive Toxicology
Volume34
Issue number2
Pages (from-to)237-250
ISSN0890-6238
DOIs
Publication statusPublished - 2012
Event40th Annual Conference of the European Teratology Society - Linz, Austria
Duration: 2 Sep 20125 Sep 2012
Conference number: 40
http://www.etsoc.com/annual_meetings

Conference

Conference40th Annual Conference of the European Teratology Society
Number40
CountryAustria
CityLinz
Period02/09/201205/09/2012
Internet address

Keywords

  • Mixture
  • Developmental toxicology
  • Male Wistar rat
  • Female Wistar rat
  • Endocrine disrupter
  • Pesticides
  • Mammary gland
  • Whole mount
  • Reproductive organs
  • Behavior
  • Estrous
  • Estrus
  • Steroid hormones
  • Sperm count
  • Thyroidea
  • Antiandrogen

Cite this

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title = "Persistent developmental toxicity in rat offspring after low dose exposure to a mixture of endocrine disrupting pesticides",
abstract = "There is growing concern of permanent damage to the endocrine and nervous systems after developmental exposure to endocrine disrupting chemicals. In this study the permanent reproductive and neurobehavioral effects of combined exposure to five endocrine disrupting pesticides, epoxiconazole, mancozeb, prochloraz, tebuconazole and procymidone, were examined. Pregnant and lactating rat dams were dosed with a mixture of the five pesticides at three different doses, or with the individual pesticides at one of two doses.Adverse effects were observed in young and adult male offspring from the group exposed to the highest dose of the mixture. These included reduced prostate and epididymis weights, increased testes weights, altered prostate histopathology, increased density of mammary glands, reduced sperm counts, and decreased spatial learning. As no significant effects were seen following single compound exposure at the doses included in the highest mixture dose, these results indicate cumulative adverse effects of the pesticide mixture.",
keywords = "Mixture, Developmental toxicology, Male Wistar rat, Female Wistar rat, Endocrine disrupter, Pesticides, Mammary gland, Whole mount, Reproductive organs, Behavior, Estrous, Estrus, Steroid hormones, Sperm count, Thyroidea, Antiandrogen",
author = "Jacobsen, {Pernille Rosenskjold} and Petersen, {Marta Axelstad} and Julie Boberg and Isling, {Louise Krag} and Sofie Christiansen and Mandrup, {Karen Riiber} and Berthelsen, {Line Olrik} and Vinggaard, {Anne Marie} and Ulla Hass",
year = "2012",
doi = "10.1016/j.reprotox.2012.05.099",
language = "English",
volume = "34",
pages = "237--250",
journal = "Reproductive Toxicology",
issn = "0890-6238",
publisher = "Elsevier",
number = "2",

}

Persistent developmental toxicity in rat offspring after low dose exposure to a mixture of endocrine disrupting pesticides. / Jacobsen, Pernille Rosenskjold; Petersen, Marta Axelstad; Boberg, Julie; Isling, Louise Krag; Christiansen, Sofie; Mandrup, Karen Riiber; Berthelsen, Line Olrik; Vinggaard, Anne Marie; Hass, Ulla.

In: Reproductive Toxicology, Vol. 34, No. 2, 2012, p. 237-250.

Research output: Contribution to journalConference articleResearchpeer-review

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T1 - Persistent developmental toxicity in rat offspring after low dose exposure to a mixture of endocrine disrupting pesticides

AU - Jacobsen, Pernille Rosenskjold

AU - Petersen, Marta Axelstad

AU - Boberg, Julie

AU - Isling, Louise Krag

AU - Christiansen, Sofie

AU - Mandrup, Karen Riiber

AU - Berthelsen, Line Olrik

AU - Vinggaard, Anne Marie

AU - Hass, Ulla

PY - 2012

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N2 - There is growing concern of permanent damage to the endocrine and nervous systems after developmental exposure to endocrine disrupting chemicals. In this study the permanent reproductive and neurobehavioral effects of combined exposure to five endocrine disrupting pesticides, epoxiconazole, mancozeb, prochloraz, tebuconazole and procymidone, were examined. Pregnant and lactating rat dams were dosed with a mixture of the five pesticides at three different doses, or with the individual pesticides at one of two doses.Adverse effects were observed in young and adult male offspring from the group exposed to the highest dose of the mixture. These included reduced prostate and epididymis weights, increased testes weights, altered prostate histopathology, increased density of mammary glands, reduced sperm counts, and decreased spatial learning. As no significant effects were seen following single compound exposure at the doses included in the highest mixture dose, these results indicate cumulative adverse effects of the pesticide mixture.

AB - There is growing concern of permanent damage to the endocrine and nervous systems after developmental exposure to endocrine disrupting chemicals. In this study the permanent reproductive and neurobehavioral effects of combined exposure to five endocrine disrupting pesticides, epoxiconazole, mancozeb, prochloraz, tebuconazole and procymidone, were examined. Pregnant and lactating rat dams were dosed with a mixture of the five pesticides at three different doses, or with the individual pesticides at one of two doses.Adverse effects were observed in young and adult male offspring from the group exposed to the highest dose of the mixture. These included reduced prostate and epididymis weights, increased testes weights, altered prostate histopathology, increased density of mammary glands, reduced sperm counts, and decreased spatial learning. As no significant effects were seen following single compound exposure at the doses included in the highest mixture dose, these results indicate cumulative adverse effects of the pesticide mixture.

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KW - Mammary gland

KW - Whole mount

KW - Reproductive organs

KW - Behavior

KW - Estrous

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KW - Steroid hormones

KW - Sperm count

KW - Thyroidea

KW - Antiandrogen

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JO - Reproductive Toxicology

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