Persistence of Vancomycin Resistance in Multiple Clones of Enterococcus faecium Isolated from Danish Broilers 15 Years after the Ban of Avoparcin

Valeria Bortolaia; Manuela Mander; Lars Bogø Jensen; John E. Olsen; Luca Guardabassi

doi:10.1128/AAC.05072-14

Persistence of Vancomycin Resistance in Multiple Clones of Enterococcus faecium Isolated from Danish Broilers 15 Years after the Ban of Avoparcin

Valeria Bortolaia, Manuela Mander, Lars Bogø Jensen, John E. Olsen, Luca Guardabassi

National Food Institute

University of Copenhagen

Research output: Contribution to journal › Journal article › Research › peer-review

Abstract

The occurrence and diversity of vancomycin-resistant Enterococcus faecium (VREF) were investigated in 100 Danish broiler flocks 15 years after the avoparcin ban. VREF occurred in 47 flocks at low fecal concentrations detectable only by selective enrichment. Vancomycin resistance was prevalently associated with a transferable nontypeable plasmid lineage occurring in multiple E. faecium clones. Coselection of sequence type 842 by tetracycline use only partly explained the persistence of vancomycin resistance in the absence of detectable plasmid coresistance and toxin-antitoxin systems.

Original language	English
Journal	Antimicrobial Agents and Chemotherapy
Volume	59
Issue number	5
Pages (from-to)	2926-2929
Number of pages	4
ISSN	0066-4804
DOIs	https://doi.org/10.1128/AAC.05072-14
Publication status	Published - 2015

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title = "Persistence of Vancomycin Resistance in Multiple Clones of Enterococcus faecium Isolated from Danish Broilers 15 Years after the Ban of Avoparcin",

abstract = "The occurrence and diversity of vancomycin-resistant Enterococcus faecium (VREF) were investigated in 100 Danish broiler flocks 15 years after the avoparcin ban. VREF occurred in 47 flocks at low fecal concentrations detectable only by selective enrichment. Vancomycin resistance was prevalently associated with a transferable nontypeable plasmid lineage occurring in multiple E. faecium clones. Coselection of sequence type 842 by tetracycline use only partly explained the persistence of vancomycin resistance in the absence of detectable plasmid coresistance and toxin-antitoxin systems.",

author = "Valeria Bortolaia and Manuela Mander and Jensen, {Lars Bog{\o}} and Olsen, {John E.} and Luca Guardabassi",

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publisher = "American Society for Microbiology",

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Persistence of Vancomycin Resistance in Multiple Clones of Enterococcus faecium Isolated from Danish Broilers 15 Years after the Ban of Avoparcin. / Bortolaia, Valeria; Mander, Manuela; Jensen, Lars Bogø et al.
In: Antimicrobial Agents and Chemotherapy, Vol. 59, No. 5, 2015, p. 2926-2929.

Research output: Contribution to journal › Journal article › Research › peer-review

TY - JOUR

T1 - Persistence of Vancomycin Resistance in Multiple Clones of Enterococcus faecium Isolated from Danish Broilers 15 Years after the Ban of Avoparcin

AU - Bortolaia, Valeria

AU - Mander, Manuela

AU - Jensen, Lars Bogø

AU - Olsen, John E.

AU - Guardabassi, Luca

PY - 2015

Y1 - 2015

N2 - The occurrence and diversity of vancomycin-resistant Enterococcus faecium (VREF) were investigated in 100 Danish broiler flocks 15 years after the avoparcin ban. VREF occurred in 47 flocks at low fecal concentrations detectable only by selective enrichment. Vancomycin resistance was prevalently associated with a transferable nontypeable plasmid lineage occurring in multiple E. faecium clones. Coselection of sequence type 842 by tetracycline use only partly explained the persistence of vancomycin resistance in the absence of detectable plasmid coresistance and toxin-antitoxin systems.

AB - The occurrence and diversity of vancomycin-resistant Enterococcus faecium (VREF) were investigated in 100 Danish broiler flocks 15 years after the avoparcin ban. VREF occurred in 47 flocks at low fecal concentrations detectable only by selective enrichment. Vancomycin resistance was prevalently associated with a transferable nontypeable plasmid lineage occurring in multiple E. faecium clones. Coselection of sequence type 842 by tetracycline use only partly explained the persistence of vancomycin resistance in the absence of detectable plasmid coresistance and toxin-antitoxin systems.

U2 - 10.1128/AAC.05072-14

DO - 10.1128/AAC.05072-14

M3 - Journal article

C2 - 25712360

SN - 0066-4804

VL - 59

SP - 2926

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JO - Antimicrobial Agents and Chemotherapy

JF - Antimicrobial Agents and Chemotherapy

IS - 5

ER -

Persistence of Vancomycin Resistance in Multiple Clones of Enterococcus faecium Isolated from Danish Broilers 15 Years after the Ban of Avoparcin

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