TY - JOUR
T1 - Perinatal exposure to mixtures of endocrine disrupting chemicals reduces female rat follicle reserves and accelerates reproductive aging
AU - Johansson, Hanna Katarina Lilith
AU - Jacobsen, Pernille Rosenskjold
AU - Hass, Ulla
AU - Svingen, Terje
AU - Vinggaard, Anne Marie
AU - Isling, Louise Krag
AU - Axelstad, Marta
AU - Christiansen, Sofie
AU - Boberg, Julie
PY - 2016
Y1 - 2016
N2 - Exposure to endocrine disrupting chemicals (EDCs) during development can have negative consequences later in life. In this study we investigated the effect of perinatal exposure to mixtures of human relevant EDCs on the female reproductive system. Rat dams were exposed to a mixture of phthalates, pesticides, UV-filters, bisphenol A, butyl-paraben, as well as paracetamol. The compounds were tested together (Totalmix) or in subgroups with anti-androgenic (AAmix) or estrogenic (Emix) potentials. Paracetamol was tested separately. In pre-pubertal rats, a significant reduction in primordial follicle numbers was seen in AAmix and PM groups, and reduced plasma levels of prolactin was seen in AAmix. In one-year-old animals, the incidence of irregular estrous cycles was higher after Totalmix-exposure and reduced ovary weights were seen in Totalmix, AAmix, and PM groups. These findings resemble premature ovarian insufficiency in humans, and raises concern regarding potential effects of mixtures of EDCs on female reproductive function.
AB - Exposure to endocrine disrupting chemicals (EDCs) during development can have negative consequences later in life. In this study we investigated the effect of perinatal exposure to mixtures of human relevant EDCs on the female reproductive system. Rat dams were exposed to a mixture of phthalates, pesticides, UV-filters, bisphenol A, butyl-paraben, as well as paracetamol. The compounds were tested together (Totalmix) or in subgroups with anti-androgenic (AAmix) or estrogenic (Emix) potentials. Paracetamol was tested separately. In pre-pubertal rats, a significant reduction in primordial follicle numbers was seen in AAmix and PM groups, and reduced plasma levels of prolactin was seen in AAmix. In one-year-old animals, the incidence of irregular estrous cycles was higher after Totalmix-exposure and reduced ovary weights were seen in Totalmix, AAmix, and PM groups. These findings resemble premature ovarian insufficiency in humans, and raises concern regarding potential effects of mixtures of EDCs on female reproductive function.
KW - Endocrine disruption
KW - Anti-Androgen
KW - Female Reproductive System
KW - Ovarian Toxicology
KW - Follicle
KW - Estrous cycle
KW - Reproductive senescence
U2 - 10.1016/j.reprotox.2016.03.045
DO - 10.1016/j.reprotox.2016.03.045
M3 - Journal article
C2 - 27049580
SN - 0890-6238
VL - 61
SP - 186
EP - 194
JO - Reproductive Toxicology
JF - Reproductive Toxicology
ER -