Performance Improvement by Layout Designs of Conductive Polymer Microelectrode Based Impedimetric Biosensors

Giulio Rosati, Johannes Daprà, Solène Cherré, Noemi Rozlosnik

    Research output: Contribution to journalJournal articleResearchpeer-review

    Abstract

    In this work we present a theoretical, computational, and experimental evaluation of the performance of an impedimetric biosensor based on interdigitated conductive polymer (PEDOT:TsO) microelectrodes in a microfluidic system. The influence of the geometry of the electrodes and microchannels on the electrochemical performance of the biosensor was exploited to improve the detection system. The developed model allowed us to predict the performance of the electrochemical system, and thus to optimize the geometry for electrochemical impedance spectroscopy (EIS). Finally, the optimized electrode design was validated by the detection of a clinically relevant target (ampicillin) at picomolar concentrations.
    Original languageEnglish
    JournalElectroanalysis
    Volume26
    Issue number6
    Pages (from-to)1400-1408
    Number of pages9
    ISSN1040-0397
    DOIs
    Publication statusPublished - 2014

    Keywords

    • Electrochemistry
    • Conductive polymers
    • Microelectrodes
    • PEDOT
    • Aptamer
    • Ampicillin

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