Peptides and metallic nanoparticles for biomedical applications

Marcelo J. Kogan, Ivonne Olmedo, Leticia Hosta Rigau, Ariel R. Guerrero, Luis Javier Cruz, Fernando Albericio

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

hIn this review, we describe the contribution of peptides to the biomedical applications of metallic nanoparticles. We also discuss strategies for the preparation of peptide-nanoparticle conjugates and the synthesis of the peptides and metallic nanoparticles. An overview of the techniques used for the characterization of the conjugates is also provided. Mainly for biomedical purposes, metallic nanoparticles conjugated to peptides have been prepared from Au and iron oxide (magnetic nanoparticles). Peptides with the capacity to penetrate the plasma membrane are used to deliver nanoparticles to the cell. In addition, peptides that recognize specific cell receptors are used for targeting nanoparticles. The potential application of peptide-nanoparticle conjugates in cancer and Alzheimer's disease therapy is discussed. Several peptide-nanoparticle conjugates show biocompatibility and present a low degree of cytotoxicity. Furthermore, several peptide-metallic nanoparticle conjugates are used for in vitro diagnosis.
Original languageEnglish
JournalNanomedicine
Volume2
Issue number3
Pages (from-to)287-306
Number of pages20
ISSN1743-5889
DOIs
Publication statusPublished - 2007
Externally publishedYes

Keywords

  • Au nanoparticles
  • Biocompatibility
  • Drug delivery
  • Hyperthermia
  • In vitro assays
  • Iron oxide nanoparticles
  • Magnetic resonance imaging
  • Nanoparticle functionalization
  • Nanoparticle stabilization
  • Targeting

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