Peptide Nucleic Acids Having Enhanced Binding Affinity, Sequence Specificity and Solubility

Ole Buchardt (Inventor), Michael Engholm (Inventor), Peter E. Nielsen (Inventor), Rolf Henrik Berg (Inventor)

    Research output: Patent

    581 Downloads (Pure)

    Abstract

    A novel class of compounds, known as peptide nucleic acids, bind complementary DNA and RNA strands more strongly than a corresponding DNA strand, and exhibit increased sequence specificity and solubility. The peptide nucleic acids comprise ligands selected from a group consisting of naturally-occurring nucleobases and non-naturally-occurring nucleobases attached to a polyamide backbone, and contain C1-C8 alkylamine side chains. Methods of enhancing the solubility, binding affinity and sequence specificity of PNAs are provided.
    Original languageEnglish
    Patent numberUS5736336
    Filing date07/04/1998
    Country/TerritoryDenmark
    Publication statusPublished - 1998

    Bibliographical note

    Also published as: US5714331 (A)

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