Peptide Nucleic Acids Having Enhanced Binding Affinity and Sequence Specificity

Ole Buchardt (Inventor), Michael Engholm (Inventor), Peter E. Nielsen (Inventor), Rolf Henrik Berg (Inventor)

    Research output: Patent

    234 Downloads (Pure)


    A novel class of compounds, known as peptide nucleic acids, bind complementary DNA and RNA strands more strongly than a corresponding DNA strand, and exhibit increased sequence specificity and binding affinity. Methods of increasing binding affinity and sequence specificity of peptide nucleic acids are provided wherein some peptide nucleic acids comprise ligands selected from a group consisting of naturally-occurring nucleobases and non-naturally-occurring nucleobases attached to a polyamide backbone, while other peptide nucleic acids contain at least one 2,6-diaminopurine nucleobase and at least one C1-C8 alkylamine side chain.
    Original languageEnglish
    Patent numberUS5766855
    Filing date16/06/1998
    Publication statusPublished - 1998


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