Peptide Nucleic Acids Having Amino Acid Side Chains

Ole Buchardt (Inventor), Michael Engholm (Inventor), Peter E. Nielsen (Inventor), Rolf Henrik Berg (Inventor)

    Research output: Patent

    145 Downloads (Pure)


    A novel class of compounds, known as peptide nucleic acids, bind complementary DNA and RNA strands more strongly than the corresponding DNA or RNA strands, and exhibit increased sequence specificity and solubility. The peptide nucleic acids comprise ligands selected from a group consisting of naturally-occurring nucleobases and non-naturally-occurring nucleobases attached to a polyamide backbone, and contain alkylamine side chains.
    Original languageEnglish
    Patent numberUS5786461
    Filing date28/07/1998
    Publication statusPublished - 1998

    Bibliographical note

    Also published as: US5719262 (A)


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