Peptide Nucleic Acids Having 2,6-Diaminopurine Nucleobases

Ole Buchardt (Inventor), Michael Engholm (Inventor), Peter E. Nielsen (Inventor), Rolf Henrik Berg (Inventor)

    Research output: Patent

    145 Downloads (Pure)

    Abstract

    A novel class of compounds, known as peptide nucleic acids, bind complementary DNA and RNA strands more strongly than a corresponding DNA strand, and exhibit increased sequence specificity and binding affinity. The peptide nucleic acids of the invention comprise ligands selected from a group consisting of naturally-occurring nucleobases and non-naturally-occurring nucleobases attached to a polyamide backbone. Some PNAs of the invention also contain C1-C8 alkylamine side chains.
    Original languageEnglish
    Patent numberUS6613873
    Filing date02/09/2003
    Country/TerritoryDenmark
    Publication statusPublished - 2003

    Bibliographical note

    Also Published as: US6414112 (B1) US2002146718 (A1) US6613873 (B1)

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