Peptide Nucleic Acids Having 2,6-Diaminopurine Nucleobases

Ole Buchardt; Michael Engholm; Peter E. Nielsen; Rolf Henrik Berg

Peptide Nucleic Acids Having 2,6-Diaminopurine Nucleobases

Ole Buchardt (Inventor)
, Michael Engholm (Inventor)
, Peter E. Nielsen (Inventor)
, Rolf Henrik Berg (Inventor)

University of Copenhagen

Research output: Patent

278 Downloads (Orbit)

Abstract

A novel class of compounds, known as peptide nucleic acids, bind complementary DNA and RNA strands more strongly than a corresponding DNA strand, and exhibit increased sequence specificity and binding affinity. The peptide nucleic acids of the invention comprise ligands selected from a group consisting of naturally-occurring nucleobases and non-naturally-occurring nucleobases attached to a polyamide backbone. Some PNAs of the invention also contain C1-C8 alkylamine side chains.

Original language	English
Patent number	US6613873
Filing date	02/09/2003
Country/Territory	Denmark
Publication status	Published - 2003

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Also Published as: US6414112 (B1) US2002146718 (A1) US6613873 (B1)

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title = "Peptide Nucleic Acids Having 2,6-Diaminopurine Nucleobases",

abstract = "A novel class of compounds, known as peptide nucleic acids, bind complementary DNA and RNA strands more strongly than a corresponding DNA strand, and exhibit increased sequence specificity and binding affinity. The peptide nucleic acids of the invention comprise ligands selected from a group consisting of naturally-occurring nucleobases and non-naturally-occurring nucleobases attached to a polyamide backbone. Some PNAs of the invention also contain C1-C8 alkylamine side chains.",

author = "Ole Buchardt and Michael Engholm and Nielsen, \{Peter E.\} and Berg, \{Rolf Henrik\}",

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year = "2003",

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T1 - Peptide Nucleic Acids Having 2,6-Diaminopurine Nucleobases

AU - Buchardt, Ole

AU - Engholm, Michael

AU - Nielsen, Peter E.

AU - Berg, Rolf Henrik

N1 - Also Published as: US6414112 (B1) US2002146718 (A1) US6613873 (B1)

PY - 2003

Y1 - 2003

N2 - A novel class of compounds, known as peptide nucleic acids, bind complementary DNA and RNA strands more strongly than a corresponding DNA strand, and exhibit increased sequence specificity and binding affinity. The peptide nucleic acids of the invention comprise ligands selected from a group consisting of naturally-occurring nucleobases and non-naturally-occurring nucleobases attached to a polyamide backbone. Some PNAs of the invention also contain C1-C8 alkylamine side chains.

AB - A novel class of compounds, known as peptide nucleic acids, bind complementary DNA and RNA strands more strongly than a corresponding DNA strand, and exhibit increased sequence specificity and binding affinity. The peptide nucleic acids of the invention comprise ligands selected from a group consisting of naturally-occurring nucleobases and non-naturally-occurring nucleobases attached to a polyamide backbone. Some PNAs of the invention also contain C1-C8 alkylamine side chains.

M3 - Patent

M1 - US6613873

Y2 - 2003/09/02

ER -

Peptide Nucleic Acids Having 2,6-Diaminopurine Nucleobases

Abstract

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