Peptide nucleic acids containing adenine or guanine recognize thymine and cytosine in complementary DNA sequences

M. Egholm; C. Behrens; L. Christensen; R.H. Berg; P.E. Nielsen; O. Buchardt

doi:10.1039/C39930000800

Peptide nucleic acids containing adenine or guanine recognize thymine and cytosine in complementary DNA sequences

M. Egholm, C. Behrens, L. Christensen, R.H. Berg, P.E. Nielsen, O. Buchardt

Research output: Contribution to journal › Journal article › Research › peer-review

Abstract

Peptide nucleic acid (PNA) monomer building blocks for the introduction of G and A are prepared and used to synthesise H-T₄XT₅-Lys-NH₂(X = G or A), which are shown by T_m measurements to recognize their complementary DNA sequences in both the parallel (N-terminal PNA/5′-DNA) and the anti-parallel mode; the stoichiometry in each case is (PNA)₂/DNA.

Original language	English
Journal	Journal of the Chemical Society D: Chemical Communications
Issue number	9
Pages (from-to)	800-801
ISSN	0022-4936
DOIs	https://doi.org/10.1039/C39930000800
Publication status	Published - 1993

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title = "Peptide nucleic acids containing adenine or guanine recognize thymine and cytosine in complementary DNA sequences",

abstract = "Peptide nucleic acid (PNA) monomer building blocks for the introduction of G and A are prepared and used to synthesise H-T4XT5-Lys-NH2(X = G or A), which are shown by Tm measurements to recognize their complementary DNA sequences in both the parallel (N-terminal PNA/5′-DNA) and the anti-parallel mode; the stoichiometry in each case is (PNA)2/DNA.",

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T1 - Peptide nucleic acids containing adenine or guanine recognize thymine and cytosine in complementary DNA sequences

AU - Egholm, M.

AU - Behrens, C.

AU - Christensen, L.

AU - Berg, R.H.

AU - Nielsen, P.E.

AU - Buchardt, O.

PY - 1993

Y1 - 1993

N2 - Peptide nucleic acid (PNA) monomer building blocks for the introduction of G and A are prepared and used to synthesise H-T4XT5-Lys-NH2(X = G or A), which are shown by Tm measurements to recognize their complementary DNA sequences in both the parallel (N-terminal PNA/5′-DNA) and the anti-parallel mode; the stoichiometry in each case is (PNA)2/DNA.

AB - Peptide nucleic acid (PNA) monomer building blocks for the introduction of G and A are prepared and used to synthesise H-T4XT5-Lys-NH2(X = G or A), which are shown by Tm measurements to recognize their complementary DNA sequences in both the parallel (N-terminal PNA/5′-DNA) and the anti-parallel mode; the stoichiometry in each case is (PNA)2/DNA.

KW - Materialer med særlige fysiske og kemiske egenskaber

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DO - 10.1039/C39930000800

M3 - Journal article

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JO - Journal of the Chemical Society D: Chemical Communications

JF - Journal of the Chemical Society D: Chemical Communications

IS - 9

ER -

Peptide nucleic acids containing adenine or guanine recognize thymine and cytosine in complementary DNA sequences

Abstract

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