Peptide nucleic acids and their potential applications in biotechnology

O. Buchardt, M. Egholm, R.H. Berg, P.E. Nielsen

    Research output: Contribution to journalJournal articleResearch

    Abstract

    Peptide nucleic acids (PNAs) are novel DNA mimics in which the sugar-phosphate backbone has been replaced with a backbone based on amino acids1-3. PNAs exhibit sequence-specific binding to DNA and RNA with higher affinities and specificities than unmodified DNA. They,are resistant to nuclease and protease attack in serum and cellular extracts and, thus, appear very promising as diagnostic and biomolecular probes, and possibly as antisense and antigene drugs.
    Original languageEnglish
    JournalTrends in Biotechnology
    Volume11
    Issue number9
    Pages (from-to)384-386
    ISSN0167-7799
    DOIs
    Publication statusPublished - 1993

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