TY - JOUR
T1 - Peptide nucleic acids and their potential applications in biotechnology
AU - Buchardt, O.
AU - Egholm, M.
AU - Berg, R.H.
AU - Nielsen, P.E.
PY - 1993
Y1 - 1993
N2 - Peptide nucleic acids (PNAs) are novel DNA mimics in which the sugar-phosphate backbone has been replaced with a backbone based on amino acids1-3. PNAs exhibit sequence-specific binding to DNA and RNA with higher affinities and specificities than unmodified DNA. They,are resistant to nuclease and protease attack in serum and cellular extracts and, thus, appear very promising as diagnostic and biomolecular probes, and possibly as antisense and antigene drugs.
AB - Peptide nucleic acids (PNAs) are novel DNA mimics in which the sugar-phosphate backbone has been replaced with a backbone based on amino acids1-3. PNAs exhibit sequence-specific binding to DNA and RNA with higher affinities and specificities than unmodified DNA. They,are resistant to nuclease and protease attack in serum and cellular extracts and, thus, appear very promising as diagnostic and biomolecular probes, and possibly as antisense and antigene drugs.
KW - Materialer med særlige fysiske og kemiske egenskaber
U2 - 10.1016/0167-7799(93)90097-S
DO - 10.1016/0167-7799(93)90097-S
M3 - Journal article
SN - 0167-7799
VL - 11
SP - 384
EP - 386
JO - Trends in Biotechnology
JF - Trends in Biotechnology
IS - 9
ER -