Peptide Nucleic Acids

Peter E. Nielsen (Inventor), Michael Engholm (Inventor), Rolf Henrik Berg (Inventor), Ole Buchardt (Inventor)

    Research output: Patent

    351 Downloads (Pure)


    A novel class of compounds known as peptide nucleic acids, bind complementary DNA and RNA strands, and generally do so more strongly than the corresponding DNA or RNA strands while exhibiting increased sequence specificity and solubility. The peptide nucleic acids comprise ligands selected from a group consisting of naturally-occurring nucleobases and non-naturally-occurring nucleobases, including 2,6-diaminopurine, attached to a polyamide backbone, and contain alkyl amine side chains.
    Original languageEnglish
    Patent numberUS6710164
    Filing date23/03/2004
    Publication statusPublished - 2004


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