Peptide Nucleic Acids

Peter E. Nielsen; Michael Engholm; Rolf Henrik Berg; Ole Buchardt

Peptide Nucleic Acids

Peter E. Nielsen (Inventor), Michael Engholm (Inventor), Rolf Henrik Berg (Inventor), Ole Buchardt (Inventor)

University of Copenhagen

Research output: Patent

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Abstract

A novel class of compounds known as peptide nucleic acids, bind complementary DNA and RNA strands, and generally do so more strongly than the corresponding DNA or RNA strands while exhibiting increased sequence specificity and solubility. The peptide nucleic acids comprise ligands selected from a group consisting of naturally-occurring nucleobases and non-naturally-occurring nucleobases, including 2,6-diaminopurine, attached to a polyamide backbone, and contain alkyl amine side chains.

Original language	English
Patent number	US6710164
Filing date	23/03/2004
Country/Territory	Denmark
Publication status	Published - 2004

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title = "Peptide Nucleic Acids",

abstract = "A novel class of compounds known as peptide nucleic acids, bind complementary DNA and RNA strands, and generally do so more strongly than the corresponding DNA or RNA strands while exhibiting increased sequence specificity and solubility. The peptide nucleic acids comprise ligands selected from a group consisting of naturally-occurring nucleobases and non-naturally-occurring nucleobases, including 2,6-diaminopurine, attached to a polyamide backbone, and contain alkyl amine side chains.",

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AU - Berg, Rolf Henrik

AU - Buchardt, Ole

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M3 - Patent

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Peptide Nucleic Acids

Abstract

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