Pay attention to the biological nanoparticles when studying the protein corona on nanomedicines

Jens B. Simonsen*, Rasmus Dithmar Münter

*Corresponding author for this work

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

The protein corona of nanoparticles has in recent years received considerable attention, and even been postulated to be the missing link in the translation of nanomedicines from benchtop to bedside. Here, we highlight the different types of biological nanoparticles present in blood that need to be considered in the protein corona research field. We map their size, density and plasma concentrations and use this information to stress potential challenges related to the isolation of nanomedicines, with particular focus on liposomes, when using the traditional isolation methods that separate according to size and density.
Original languageEnglish
JournalAngewandte Chemie International Edition
Volume59
Issue number31
Pages (from-to)12584-12588
ISSN1433-7851
DOIs
Publication statusPublished - 2020

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