TY - JOUR
T1 - Pay attention to the biological nanoparticles when studying the protein corona on nanomedicines
AU - Simonsen, Jens B.
AU - Münter, Rasmus Dithmar
PY - 2020
Y1 - 2020
N2 - The protein corona of nanoparticles has in recent years received considerable attention, and even been postulated to be the missing link in the translation of nanomedicines from benchtop to bedside. Here, we highlight the different types of biological nanoparticles present in blood that need to be considered in the protein corona research field. We map their size, density and plasma concentrations and use this information to stress potential challenges related to the isolation of nanomedicines, with particular focus on liposomes, when using the traditional isolation methods that separate according to size and density.
AB - The protein corona of nanoparticles has in recent years received considerable attention, and even been postulated to be the missing link in the translation of nanomedicines from benchtop to bedside. Here, we highlight the different types of biological nanoparticles present in blood that need to be considered in the protein corona research field. We map their size, density and plasma concentrations and use this information to stress potential challenges related to the isolation of nanomedicines, with particular focus on liposomes, when using the traditional isolation methods that separate according to size and density.
U2 - 10.1002/anie.202004611
DO - 10.1002/anie.202004611
M3 - Journal article
C2 - 32347625
SN - 1433-7851
VL - 59
SP - 12584
EP - 12588
JO - Angewandte Chemie International Edition
JF - Angewandte Chemie International Edition
IS - 31
ER -