Patulin and secondary metabolite production by marine-derived Penicillium strains

Marieke Vansteelandt, Isabelle Kerzaon, Elodie Blanchet, Olivia Fossi Tankoua, Thibaut Robiou Du Pont, Yolaine Joubert, Fabrice Monteau, Bruno Le Bizec, Jens C. Frisvad, Yves François Pouchus, Olivier Grovel

    Research output: Contribution to journalJournal articleResearchpeer-review

    Abstract

    Genus Penicillium represents an important fungal group regarding to its mycotoxin production. Secondary metabolomes of eight marine-derived strains belonging to subgenera Furcatum and Penicillium were investigated using dereplication by liquid chromatography (LC)–Diode Array Detector (DAD)–mass spectrometry (MS)/MS. Each strain was grown on six different culture media to enhance the number of observable metabolites.Thirty-two secondary metabolites were detected in crude extracts with twenty first observations for studied species. Patulin, a major mycotoxin, was classically detected in extracts of Penicillium expansum, and was also isolated from Penicillium antarcticum cultures, whose secondary metabolome is still to be done. These detections constituted the first descriptions of patulin in marine strains of Penicillium, highlighting the risk for shellfish and their consumers due to the presence of these fungi in shellfish farming areas.Patulin induced acute neurotoxicity on Diptera larvae, indicating the interest of this bioassay as an additional tool for detection of this major mycotoxin in crude extracts.
    Original languageEnglish
    JournalFungal Biology
    Volume116
    Issue number9
    Pages (from-to)954-961
    ISSN1878-6146
    DOIs
    Publication statusPublished - 2012

    Keywords

    • LC–DAD–MS/MS dereplication
    • Marine-derived Penicillium
    • Neuroactivity
    • Patulin
    • Secondary metabolites
    • Subgenus Furcatum

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