Pattern formation by a cell surface-associated morphogen in Myxococcus xanthus

Lars Jelsbak, Lotte Sogaard-Andersen

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Abstract

In response to starvation, an unstructured population of identical Myxococcus xanthus cells rearranges into an asymmetric, stable pattern of multicellular fruiting bodies. Central to this pattern formation process are changes in organized cell movements from swarming to aggregation. Aggregation is induced by the cell surface-associated C-signal. To understand how aggregation is accomplished, we have analyzed how C-signal modulates cell behavior. We show that C-signal induces a motility response that includes increases in transient gliding speeds and in the duration of gliding intervals and decreases in stop and reversal frequencies. This response results in a switch in cell behavior from an oscillatory to a unidirectional type of behavior in which the net-distance traveled by a cell per minute is increased. We propose that the C-signal-dependent regulation of the reversal frequency is essential for aggregation and that the remaining C-signal-dependent changes in motility parameters contribute to aggregation by increasing the net-distance traveled by starving cells per minute. In our model for symmetry-breaking and aggregation, C-signal transmission is a local event involving direct contacts between cells that results in a global organization of cells. This pattern formation mechanism does not require a diffusible substance or other actions at a distance. Rather it depends on contact-induced changes in motility behavior to direct cells appropriately.
Original languageEnglish
JournalProceedings of the National Academy of Sciences of the United States of America
Volume99
Issue number4
Pages (from-to)2032-2037
Number of pages6
ISSN0027-8424
DOIs
Publication statusPublished - 2002
Externally publishedYes

Keywords

  • Bacterial Proteins
  • Cell Communication
  • Cell Division
  • Cell Movement
  • Microscopy, Video
  • Myxococcus xanthus
  • Signal Transduction
  • Time Factors
  • CsgA protein, Myxococcus xanthus
  • C-signal
  • cell behavior switch
  • gliding intervals
  • pattern formation
  • Myxococcales Fruiting Gliding Bacteria - The Myxobacteria Eubacteria Bacteria Microorganisms (Bacteria, Eubacteria, Microorganisms) - Myxococcaceae [08713] Myxococcus xanthus
  • cell surface-associated morphogen
  • 02502, Cytology - General
  • 10060, Biochemistry studies - General
  • 30500, Morphology and cytology of bacteria
  • 31000, Physiology and biochemistry of bacteria
  • Biochemistry and Molecular Biophysics
  • Cell Biology

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