Pathway and network analysis of cancer genomes

Pau Creixell, Jueri Reimand, Syed Haider, Guanming Wu, Tatsuhiro Shibata, Miguel Vazquez, Ville Mustonen, Abel Gonzalez-Perez, John Pearson, Chris Sander, Rune Linding

    Research output: Contribution to journalJournal articleResearchpeer-review


    Genomic information on tumors from 50 cancer types cataloged by the International Cancer Genome Consortium (ICGC) shows that only a few well-studied driver genes are frequently mutated, in contrast to many infrequently mutated genes that may also contribute to tumor biology. Hence there has been large interest in developing pathway and network analysis methods that group genes and illuminate the processes involved. We provide an overview of these analysis techniques and show where they guide mechanistic and translational investigations.
    Original languageEnglish
    JournalNature Methods
    Issue number7
    Pages (from-to)615-621
    Number of pages7
    Publication statusPublished - 2015

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