Abstract
The publication of the Process Analytical Technology (PAT) guidance has been one of the most important milestones for pharmaceutical production during the past ten years. The ideas outlined in the PAT guidance are also applied in other industries, for example the fermentation industry. Process knowledge is central in PAT projects. This manuscript therefore gives a brief overview of a number of PAT tools for collecting process knowledge on fermentation processes: on-line sensors, mechanistic models and small-scale equipment for high-throughput experimentation. The manuscript ends with a short perspective on future developments.
Original language | English |
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Journal | Chimica Oggi – Chemistry Today |
Volume | 30 |
Issue number | 3 |
Pages (from-to) | 38-42 |
ISSN | 0392-839X |
Publication status | Published - 2012 |
Keywords
- Biotechnology
- Chemistry
- Near-infrared spectroscop
- Software sensors
- Pichia-Pastoris
- Process design
- Optimization
- Online
- Cells