PAT tools for fermentation processes

Krist Gernaey, Andrijana Bolic, Bent Svanholm

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

The publication of the Process Analytical Technology (PAT) guidance has been one of the most important milestones for pharmaceutical production during the past ten years. The ideas outlined in the PAT guidance are also applied in other industries, for example the fermentation industry. Process knowledge is central in PAT projects. This manuscript therefore gives a brief overview of a number of PAT tools for collecting process knowledge on fermentation processes: on-line sensors, mechanistic models and small-scale equipment for high-throughput experimentation. The manuscript ends with a short perspective on future developments.
Original languageEnglish
JournalChimica Oggi – Chemistry Today
Volume30
Issue number3
Pages (from-to)38-42
ISSN0392-839X
Publication statusPublished - 2012

Keywords

  • Biotechnology
  • Chemistry
  • Near-infrared spectroscop
  • Software sensors
  • Pichia-Pastoris
  • Process design
  • Optimization
  • Online
  • Cells

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