PAT tools for fermentation processes

The publication of the Process Analytical Technology (PAT) guidance has been one of the most important milestones for
pharmaceutical production during the past ten years. The ideas outlined in the PAT guidance are also applied in other
industries, for example the fermentation industry. Process knowledge is central in PAT projects. This presentation
therefore gives a brief overview of a number of PAT tools for collecting process knowledge on fermentation processes:
- On-line sensors, where for example spectroscopic measurements are increasingly applied
- Mechanistic models, which can be used to summarize process knowledge, to support experimental work, and
also within design of PAT systems
- Small-scale equipment for high-throughput experimentation, a field which has been researched intensively
during the past decade
The presentation ends with a short perspective on future developments