Passive immunization of pigs against experimental infection with Streptococcus suis serotype 2

Lars Ole Andresen, Conny Tegtmeier

    Research output: Contribution to journalJournal articleResearchpeer-review

    Abstract

    The safety and protective efficacy of a horse antiserum raised against inactivated whole cell preparations of Streptococcus suis serotype 2 was investigated in pigs by experimental challenge. The antiserum was evaluated in two similar experiments each comprising 12 4-week-old pigs treated with 6 ml of antiserum the day before challenge and four pigs used as challenge controls. Pigs were infected by subcutaneous injection with approximately 10(11) colony forming units of S. suis serotype 2. Clinical disease in the pigs that could be attributed to infection with S. suis was reduced from 88 to 35% (P = 0.015). The percentage of pigs with lesions that could be associated with S. suis was reduced from 88 to 22% (P = 0.002) and isolation of S. suis serotype 2 was reduced from five (63%) out of eight pigs in the combined challenge control groups to 3 (13%) out of 23 pigs in the combined treatment groups. These results indicate that passive immunization of pigs may be a way to reduce or control S. suis serotype 2 infections in pigs.
    Original languageEnglish
    JournalVeterinary Microbiology
    Volume81
    Issue number4
    Pages (from-to)331-344
    ISSN0378-1135
    DOIs
    Publication statusPublished - 2001

    Keywords

    • protection
    • immunization
    • challenge
    • pig-bacteria
    • capsule
    • Streptococcus suis

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