Parental age in relation to the severity of cleft lip and/or palate

Nuno V. Hermann*, Tron A. Darvann, Anders Munch, Sven Kreiborg

*Corresponding author for this work

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

Objective: To investigate parental age in relation to the severity of cleft diagnosis in a population-based consecutive sample of individuals with clefts. Setting/Sample: Retrospective, consecutive. Material/Methods: The sample comprised 545 consecutive cases with nonsyndromic clefts (437 individuals with cleft lip with/without cleft palate [CL ± P] and 106 individuals with isolated cleft palate [CP]) and parental ages recorded. The groups were subdivided according to the extent/severity of cleft. Unilateral clefts were divided according to left/right sidedness. Logistic regression was used to analyse the association between parental age and risk of severe cleft separately for CL ± P and CP, as well as between parental age and risk of right-sided cleft. Results: In CL ± P, the risk of a complete cleft in the offspring increases with maternal age when the paternal age exceeds approximately 29 years. Moreover, the risk is higher when both parents are old than when both parents are young. In CP, no statistically significant results were identified. However, there were clear trends that indicated a similar pattern as that for CL ± P. No association was identified between increased parental age and the sidedness of clefts. Conclusions: Parental age seems to contribute to cleft severity, as older parents showed a higher risk of having offspring with a complete cleft than younger parents.

Original languageEnglish
JournalOrthodontics and Craniofacial Research
Volume21
Issue number4
Pages (from-to)236-241
Number of pages6
ISSN1601-6335
DOIs
Publication statusPublished - 2018

Keywords

  • Cleft lip
  • Cleft palate
  • Humans
  • Parents
  • Retrospective studies

Fingerprint Dive into the research topics of 'Parental age in relation to the severity of cleft lip and/or palate'. Together they form a unique fingerprint.

Cite this