Paramagnetic Liposome Nanoparticles for Cellular and Tumour Imaging

Nazila Kamaly, Andrew D. Miller

Research output: Contribution to journalJournal articleResearchpeer-review

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Abstract

In this review we discuss the development of paramagnetic liposomes incorporating MRI contrast agents and show how these are utilized in cellular imaging in vitro. Bi-functional, bi-modal imaging paramagnetic liposome systems are also described. Next we discuss the upgrading of paramagnetic liposomes into bi-modal imaging neutral nanoparticles for in vivo imaging applications. We discuss the development of such systems and show how paramagnetic liposomes and imaging nanoparticles could be developed as platforms for future multi-functional, multi-modal imaging theranostic nanodevices tailor-made for the combined imaging of early stage disease pathology and functional drug delivery.
Original languageEnglish
JournalJournal of Molecular Science
Volume11
Pages (from-to)1759–1776
ISSN1000-9035
Publication statusPublished - 2010
Externally publishedYes

Keywords

  • Cellular labeling
  • Liposomes
  • Gadolinium
  • Paramagnetic liposomes
  • Bimodal liposomes
  • Cellular imaging
  • Tumour imaging
  • MRI
  • MRI contrast agents
  • Nanoparticles
  • Magnetic nanoparticles

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