Parallelized system for biopolymer degradation studies through automated microresonator measurement in liquid flow

Andrea Casci Ceccacci, Lidia Morelli, Filippo Bosco, Robert Burger, C. H. Chen, E. T. Hwu, Anja Boisen

Research output: Chapter in Book/Report/Conference proceedingArticle in proceedingsResearchpeer-review

Abstract

In this work we present a novel automated system which allows the study of enzymatic degradation of biopolymer films coated on micromechanical resonators. The system combines an optical readout based on Blu-Ray technology with a software-controlled scanning mechanism. Integrated with a microfluidic setup unit, the system allows high-throughput measurements of resonance frequency over microresonator arrays under controlled flow conditions. We here demonstrate the acquisition of statistical data on biopolymer films degradation under enzymatic reaction over a large sample of micromechanical resonators. The system has been proved to be able to perform measurements both in air and in liquid environment.
Original languageEnglish
Title of host publication19th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2015
Number of pages3
PublisherChemical and Biological Microsystems Society
Publication date2015
Pages1870-1872
ISBN (Electronic)9780979806483
Publication statusPublished - 2015
EventMicroTAS 2015: 19th International Conference on Miniaturized Systems for Chemistry and Life Sciences - Gyeongju, Korea, Republic of
Duration: 25 Oct 201529 Oct 2015
Conference number: 19

Conference

ConferenceMicroTAS 2015
Number19
CountryKorea, Republic of
CityGyeongju
Period25/10/201529/10/2015

Keywords

  • Control and Systems Engineering
  • Automation
  • Biomolecules
  • Resonators
  • Blu-ray technology
  • Enzymatic Degradation
  • Enzymatic reaction
  • High-throughput measurements
  • Liquid environment
  • Micro-resonator arrays
  • Resonance frequencies
  • Scanning mechanisms
  • Micromechanical resonators

Cite this

Casci Ceccacci, A., Morelli, L., Bosco, F., Burger, R., Chen, C. H., Hwu, E. T., & Boisen, A. (2015). Parallelized system for biopolymer degradation studies through automated microresonator measurement in liquid flow. In 19th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2015 (pp. 1870-1872). Chemical and Biological Microsystems Society.