Paper-Based Digital Microfluidic Chip for Multiple Electrochemical Assay Operated by a Wireless Portable Control System

Nipapan Ruecha, Jumi Lee, Heedo Chae, Haena Cheong, Veasna Soum, Pattarachaya Preechakasedkit, Orawon Chailapakul, Georgi Plamenov Tanev, Jan Madsen, Nadnudda Rodthongkum, Oh-Sun Kwon, Kwanwoo Shin

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

The printing and modular fabrication of a paper-based active microfluidic lab
on a chip implemented with electrochemical sensors (ECSs) is developed
and integrated on a portable electrical control system. The electrodes of a
chip plate for active electrowetting actuation of digital drops and an ECS for
multiple analysis assays are fabricated by affordable printing techniques. For
enhanced sensitivity of the sensor, the working electrode is modified through
the electrochemical method, namely by reducing graphene with voltammetry
and coating gold nanoparticles by amperometry. Detachable sensor and
absorber modules are assembled modularly on an open chip plate, forming
various novel hybridized open–closed chip formats. By varying the coupled or
decoupled sensor modules, excellent detection of three diagnostic biological
molecules is demonstrated (glucose, dopamine, and uric acid in human
serum). With a newly designed portable power supply and wireless control
system, the active paper-based chip platform can be utilized as an advanced
point-of-care device for multiple assays in digital microfluidics.
Original languageEnglish
JournalAdvanced Materials Technologies
Volume2
Issue number3
Number of pages8
ISSN2365-709x
DOIs
Publication statusPublished - 2017

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