Paper-Based Digital Microfluidic Chip for Multiple Electrochemical Assay Operated by a Wireless Portable Control System

Nipapan Ruecha, Jumi Lee, Heedo Chae, Haena Cheong, Veasna Soum, Pattarachaya Preechakasedkit, Orawon Chailapakul, Georgi Plamenov Tanev, Jan Madsen, Nadnudda Rodthongkum, Oh-Sun Kwon, Kwanwoo Shin

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

The printing and modular fabrication of a paper-based active microfluidic lab
on a chip implemented with electrochemical sensors (ECSs) is developed
and integrated on a portable electrical control system. The electrodes of a
chip plate for active electrowetting actuation of digital drops and an ECS for
multiple analysis assays are fabricated by affordable printing techniques. For
enhanced sensitivity of the sensor, the working electrode is modified through
the electrochemical method, namely by reducing graphene with voltammetry
and coating gold nanoparticles by amperometry. Detachable sensor and
absorber modules are assembled modularly on an open chip plate, forming
various novel hybridized open–closed chip formats. By varying the coupled or
decoupled sensor modules, excellent detection of three diagnostic biological
molecules is demonstrated (glucose, dopamine, and uric acid in human
serum). With a newly designed portable power supply and wireless control
system, the active paper-based chip platform can be utilized as an advanced
point-of-care device for multiple assays in digital microfluidics.
Original languageEnglish
JournalAdvanced Materials Technologies
Volume2
Issue number3
Number of pages8
ISSN2365-709x
DOIs
Publication statusPublished - 2017

Cite this

Ruecha, Nipapan ; Lee, Jumi ; Chae, Heedo ; Cheong, Haena ; Soum, Veasna ; Preechakasedkit, Pattarachaya ; Chailapakul, Orawon ; Tanev, Georgi Plamenov ; Madsen, Jan ; Rodthongkum, Nadnudda ; Kwon, Oh-Sun ; Shin, Kwanwoo. / Paper-Based Digital Microfluidic Chip for Multiple Electrochemical Assay Operated by a Wireless Portable Control System. In: Advanced Materials Technologies. 2017 ; Vol. 2, No. 3.
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title = "Paper-Based Digital Microfluidic Chip for Multiple Electrochemical Assay Operated by a Wireless Portable Control System",
abstract = "The printing and modular fabrication of a paper-based active microfluidic labon a chip implemented with electrochemical sensors (ECSs) is developedand integrated on a portable electrical control system. The electrodes of achip plate for active electrowetting actuation of digital drops and an ECS formultiple analysis assays are fabricated by affordable printing techniques. Forenhanced sensitivity of the sensor, the working electrode is modified throughthe electrochemical method, namely by reducing graphene with voltammetryand coating gold nanoparticles by amperometry. Detachable sensor andabsorber modules are assembled modularly on an open chip plate, formingvarious novel hybridized open–closed chip formats. By varying the coupled ordecoupled sensor modules, excellent detection of three diagnostic biologicalmolecules is demonstrated (glucose, dopamine, and uric acid in humanserum). With a newly designed portable power supply and wireless controlsystem, the active paper-based chip platform can be utilized as an advancedpoint-of-care device for multiple assays in digital microfluidics.",
author = "Nipapan Ruecha and Jumi Lee and Heedo Chae and Haena Cheong and Veasna Soum and Pattarachaya Preechakasedkit and Orawon Chailapakul and Tanev, {Georgi Plamenov} and Jan Madsen and Nadnudda Rodthongkum and Oh-Sun Kwon and Kwanwoo Shin",
year = "2017",
doi = "10.1002/admt.201600267",
language = "English",
volume = "2",
journal = "Advanced Materials Technologies",
issn = "2365-709x",
publisher = "Wiley-Blackwell",
number = "3",

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Ruecha, N, Lee, J, Chae, H, Cheong, H, Soum, V, Preechakasedkit, P, Chailapakul, O, Tanev, GP, Madsen, J, Rodthongkum, N, Kwon, O-S & Shin, K 2017, 'Paper-Based Digital Microfluidic Chip for Multiple Electrochemical Assay Operated by a Wireless Portable Control System', Advanced Materials Technologies, vol. 2, no. 3. https://doi.org/10.1002/admt.201600267

Paper-Based Digital Microfluidic Chip for Multiple Electrochemical Assay Operated by a Wireless Portable Control System. / Ruecha, Nipapan; Lee, Jumi; Chae, Heedo; Cheong, Haena; Soum, Veasna; Preechakasedkit, Pattarachaya; Chailapakul, Orawon; Tanev, Georgi Plamenov; Madsen, Jan; Rodthongkum, Nadnudda; Kwon, Oh-Sun; Shin, Kwanwoo.

In: Advanced Materials Technologies, Vol. 2, No. 3, 2017.

Research output: Contribution to journalJournal articleResearchpeer-review

TY - JOUR

T1 - Paper-Based Digital Microfluidic Chip for Multiple Electrochemical Assay Operated by a Wireless Portable Control System

AU - Ruecha, Nipapan

AU - Lee, Jumi

AU - Chae, Heedo

AU - Cheong, Haena

AU - Soum, Veasna

AU - Preechakasedkit, Pattarachaya

AU - Chailapakul, Orawon

AU - Tanev, Georgi Plamenov

AU - Madsen, Jan

AU - Rodthongkum, Nadnudda

AU - Kwon, Oh-Sun

AU - Shin, Kwanwoo

PY - 2017

Y1 - 2017

N2 - The printing and modular fabrication of a paper-based active microfluidic labon a chip implemented with electrochemical sensors (ECSs) is developedand integrated on a portable electrical control system. The electrodes of achip plate for active electrowetting actuation of digital drops and an ECS formultiple analysis assays are fabricated by affordable printing techniques. Forenhanced sensitivity of the sensor, the working electrode is modified throughthe electrochemical method, namely by reducing graphene with voltammetryand coating gold nanoparticles by amperometry. Detachable sensor andabsorber modules are assembled modularly on an open chip plate, formingvarious novel hybridized open–closed chip formats. By varying the coupled ordecoupled sensor modules, excellent detection of three diagnostic biologicalmolecules is demonstrated (glucose, dopamine, and uric acid in humanserum). With a newly designed portable power supply and wireless controlsystem, the active paper-based chip platform can be utilized as an advancedpoint-of-care device for multiple assays in digital microfluidics.

AB - The printing and modular fabrication of a paper-based active microfluidic labon a chip implemented with electrochemical sensors (ECSs) is developedand integrated on a portable electrical control system. The electrodes of achip plate for active electrowetting actuation of digital drops and an ECS formultiple analysis assays are fabricated by affordable printing techniques. Forenhanced sensitivity of the sensor, the working electrode is modified throughthe electrochemical method, namely by reducing graphene with voltammetryand coating gold nanoparticles by amperometry. Detachable sensor andabsorber modules are assembled modularly on an open chip plate, formingvarious novel hybridized open–closed chip formats. By varying the coupled ordecoupled sensor modules, excellent detection of three diagnostic biologicalmolecules is demonstrated (glucose, dopamine, and uric acid in humanserum). With a newly designed portable power supply and wireless controlsystem, the active paper-based chip platform can be utilized as an advancedpoint-of-care device for multiple assays in digital microfluidics.

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M3 - Journal article

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JF - Advanced Materials Technologies

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