Palladium-catalyzed aryl amination-heck cyclization cascade: A one-flask approach to 3-substituted Indoles

Thomas Jensen, Henrik Pedersen, B. Bang-Andersen, Robert Madsen, Morten Jørgensen

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

Two for the price of one: A Pd/dppf-based catalyst provides access to the title compounds from 1,2-dihalogenated aromatic compounds and allylic amines in a single reaction flask. The initial aryl amination step occurs with excellent selectivity for the aryl iodide to ensure the formation of a single indole regioisomer, which can be functionalized in situ by N-arylation (see scheme).
Original languageEnglish
JournalAngewandte Chemie - International Edition
Volume47
Issue number5
Pages (from-to)888-890
ISSN1433-7851
DOIs
Publication statusPublished - 2008

Keywords

  • palladium
  • amination
  • indoles
  • phosphane ligands
  • Heck reaction

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