Alpha Smooth Muscle Actin (a-SMA) is upregulated together with extracellular matrix (ECM) during activation of Hepatic Stellate Cells (HSCs) in fibrosis. Histone deacetylase (HDAC) remove acetylations and regulate the expression of genes, which is associated with cancers. There is a close relationship between cirrhosis and hepatocellular carcinoma (HCC), and markers enabling identification of patients in risk of developing HCC with cirrhosis is a major unmet clinical need. We developed an ELISA for the assessment of acetylated a-SMA (Aca- SMA) in serum. The objective was to investigate the ability of this marker to non-invasively diagnose hepatic fibrosis and assess the influence of HDAC in hepatocellular carcinoma (HCC).
|Journal||Journal of Hepatology|
|Publication status||Published - 2015|
|Event||The International Liver Congress™ 2015 : 50th Annual meeting of the European Association for the Study of the Liver - Vienna, Austria|
Duration: 22 Apr 2015 → 26 Apr 2015
Conference number: 50
|Conference||The International Liver Congress™ 2015|
|Period||22/04/2015 → 26/04/2015|