P0525 : N-Acetylated alpha smooth muscle actin levels are increased in hepatic fibrosis but decreased in hepatocellular carcinoma

M.J. Nielsen; Signe Holm Nielsen; N.U.B. Hansen; Jacob Hull Kristensen; M.A. Karsdal; D. J. Leeming

doi:10.1016/S0168-8278(15)30733-9

P0525 : N-Acetylated alpha smooth muscle actin levels are increased in hepatic fibrosis but decreased in hepatocellular carcinoma

M.J. Nielsen, Signe Holm Nielsen, N.U.B. Hansen, Jacob Hull Kristensen, M.A. Karsdal, D. J. Leeming

Nordic Bioscience AS

Research output: Contribution to journal › Conference abstract in journal › Research › peer-review

Abstract

Alpha Smooth Muscle Actin (a-SMA) is upregulated together with extracellular matrix (ECM) during activation of Hepatic Stellate Cells (HSCs) in fibrosis. Histone deacetylase (HDAC) remove acetylations and regulate the expression of genes, which is associated with cancers. There is a close relationship between cirrhosis and hepatocellular carcinoma (HCC), and markers enabling identification of patients in risk of developing HCC with cirrhosis is a major unmet clinical need. We developed an ELISA for the assessment of acetylated a-SMA (Aca- SMA) in serum. The objective was to investigate the ability of this marker to non-invasively diagnose hepatic fibrosis and assess the influence of HDAC in hepatocellular carcinoma (HCC).

Original language	English
Article number	P0525
Journal	Journal of Hepatology
Volume	62
Pages (from-to)	S512
ISSN	0168-8278
DOIs	https://doi.org/10.1016/S0168-8278(15)30733-9
Publication status	Published - 2015
Event	The International Liver Congress™ 2015 : 50th Annual meeting of the European Association for the Study of the Liver - Vienna, Austria Duration: 22 Apr 2015 → 26 Apr 2015 Conference number: 50 http://ilc-congress.eu/

Conference

Conference	The International Liver Congress™ 2015
Number	50
Country/Territory	Austria
City	Vienna
Period	22/04/2015 → 26/04/2015
Internet address	http://ilc-congress.eu/

Bibliographical note

Poster abstract from The International Liver Congress™ 2015 – 50th Annual meeting of the European Association for the Study of the Liver

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This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/S0168-8278(15)30733-9

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title = "P0525 : N-Acetylated alpha smooth muscle actin levels are increased in hepatic fibrosis but decreased in hepatocellular carcinoma",

abstract = "Alpha Smooth Muscle Actin (a-SMA) is upregulated together with extracellular matrix (ECM) during activation of Hepatic Stellate Cells (HSCs) in fibrosis. Histone deacetylase (HDAC) remove acetylations and regulate the expression of genes, which is associated with cancers. There is a close relationship between cirrhosis and hepatocellular carcinoma (HCC), and markers enabling identification of patients in risk of developing HCC with cirrhosis is a major unmet clinical need. We developed an ELISA for the assessment of acetylated a-SMA (Aca- SMA) in serum. The objective was to investigate the ability of this marker to non-invasively diagnose hepatic fibrosis and assess the influence of HDAC in hepatocellular carcinoma (HCC).",

author = "M.J. Nielsen and Nielsen, {Signe Holm} and N.U.B. Hansen and Kristensen, {Jacob Hull} and M.A. Karsdal and Leeming, {D. J.}",

note = "Poster abstract from The International Liver Congress{\texttrademark} 2015 – 50th Annual meeting of the European Association for the Study of the Liver; The International Liver Congress{\texttrademark} 2015 : 50th Annual meeting of the European Association for the Study of the Liver, EASL ; Conference date: 22-04-2015 Through 26-04-2015",

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AU - Nielsen, M.J.

AU - Nielsen, Signe Holm

AU - Hansen, N.U.B.

AU - Kristensen, Jacob Hull

AU - Karsdal, M.A.

AU - Leeming, D. J.

N1 - Conference code: 50

PY - 2015

Y1 - 2015

N2 - Alpha Smooth Muscle Actin (a-SMA) is upregulated together with extracellular matrix (ECM) during activation of Hepatic Stellate Cells (HSCs) in fibrosis. Histone deacetylase (HDAC) remove acetylations and regulate the expression of genes, which is associated with cancers. There is a close relationship between cirrhosis and hepatocellular carcinoma (HCC), and markers enabling identification of patients in risk of developing HCC with cirrhosis is a major unmet clinical need. We developed an ELISA for the assessment of acetylated a-SMA (Aca- SMA) in serum. The objective was to investigate the ability of this marker to non-invasively diagnose hepatic fibrosis and assess the influence of HDAC in hepatocellular carcinoma (HCC).

AB - Alpha Smooth Muscle Actin (a-SMA) is upregulated together with extracellular matrix (ECM) during activation of Hepatic Stellate Cells (HSCs) in fibrosis. Histone deacetylase (HDAC) remove acetylations and regulate the expression of genes, which is associated with cancers. There is a close relationship between cirrhosis and hepatocellular carcinoma (HCC), and markers enabling identification of patients in risk of developing HCC with cirrhosis is a major unmet clinical need. We developed an ELISA for the assessment of acetylated a-SMA (Aca- SMA) in serum. The objective was to investigate the ability of this marker to non-invasively diagnose hepatic fibrosis and assess the influence of HDAC in hepatocellular carcinoma (HCC).

U2 - 10.1016/S0168-8278(15)30733-9

DO - 10.1016/S0168-8278(15)30733-9

M3 - Conference abstract in journal

SN - 0168-8278

VL - 62

SP - S512

JO - Journal of Hepatology

JF - Journal of Hepatology

M1 - P0525

T2 - The International Liver Congress™ 2015

Y2 - 22 April 2015 through 26 April 2015

ER -

P0525 : N-Acetylated alpha smooth muscle actin levels are increased in hepatic fibrosis but decreased in hepatocellular carcinoma

Abstract

Conference

Bibliographical note

UN SDGs

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