Oxygen transfer rates and requirements in oxidative biocatalysis

Asbjørn Toftgaard Pedersen, Gustav Rehn, John M. Woodley

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Abstract

Biocatalytic oxidation reactions offer several important benefits such as regio- and stereoselectivity, avoiding the use of toxic metal based catalysts and replacing oxidizing reagents by allowing the use of oxygen. In this contribution the oxygen requirements are analysed for different process scenarios, considering different biocatalyst formats and variation of the desired productivity. Also, the applicability of two different oxygen supply methods (bubbling and membrane aeration) is considered. The results indicate that growing cells could be used to reach productivities up to 3.5 g L-1h-1 without oxygen supply being limiting. Also, membrane contactors can provide a feasible oxygen supply method when bubble-less aeration is desired. However, in order to support high productivity the oxygen flux using air may be insufficient, thus requiring the use of oxygen.
Original languageEnglish
Title of host publicationProceedings of the 25th European Symposium on Computer Aided Process Engineering
EditorsKrist V. Gernaey, Jakob K. Huusom, Rafiqul Gani
Number of pages6
Volume37
PublisherElsevier
Publication date2015
Pages2111-2116
DOIs
Publication statusPublished - 2015
Event25th European Symposium on Computer Aided Process Engineering : 12th International Symposium on Process Systems Engineering - Copenhagen, Denmark
Duration: 31 May 20154 Jun 2015
http://www.pse2015escape25.dk/

Conference

Conference25th European Symposium on Computer Aided Process Engineering
Country/TerritoryDenmark
CityCopenhagen
Period31/05/201504/06/2015
Internet address
SeriesComputer Aided Chemical Engineering
ISSN1570-7946

Keywords

  • Biocatalysis
  • Oxygen requirements
  • Oxygen supply

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