Oxygen transfer rates and requirements in oxidative biocatalysis

Asbjørn Toftgaard Pedersen, Gustav Rehn, John Woodley

Research output: Contribution to conferencePosterResearch

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Biocatalytic oxidation reactions offer several important benefits such as regio- and stereoselectivity, avoiding the use of toxic metal based catalysts and replacing oxidizing reagents by allowing the use of oxygen. However, the development of biocatalytic oxidation processes is a complex task which requires simultaneous consideration of several issues regarding the process design and operation. In this work, the oxygen requirements are analysed for different process scenarios, considering different biocatalyst formats and variation of the desired productivity. Also, the applicability of two different oxygen supply methods (bubbling and membrane aeration) investigated. Hollow fibre membrane contactors present an interesting alternative for reactor aeration, creating large specific areas (area/volume) of the gas/liquid interface. The modular design of membrane contactors, scaling-up is relatively straight forward (Gabelman and Hwang, 1999), and membrane contactors are implemented for various industrial applications (Klaassen et al., 2005).
Original languageEnglish
Publication date2015
Number of pages1
Publication statusPublished - 2015
EventTowards P450 Applications: FP7 PEOPLE P4FIFTY ITN (Initial Training Network) Conference - Le Bischenberg, Bischoffsheim, France
Duration: 24 Jun 201526 Jun 2015


ConferenceTowards P450 Applications
LocationLe Bischenberg
Internet address


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