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Oxygen metabolic competition in the lactic acidotic diabetic kidney: A point of no return?

  • Christoffer Laustsen
  • , Hans Kasper Wigh Lipsø
  • , Jakob Appel Østergaard
  • , Per Mose Nielsen
  • , Allan Flyvbjerg
  • , Michael Pedersen
  • , Fredrik Palm
  • , Jan Henrik Ardenkjær-Larsen
    • Aarhus University

    Research output: Contribution to journal › Conference abstract in journal › Research › peer-review

    Abstract

    Diabetic nephropathy is directly related to renal hypoxia, with an increased mitochondrial uncoupling and increased energy demand to maintain normal renal function. Lowering the oxygen content in inspired air has shown to worsen the prognostic outcome of diabetic patients independent of glycemic control. We therefore tested the hypothesis that acutely altered renal oxygen availability alters metabolic pathways related to cellular energy production.
    Original languageEnglish
    Article number740.7
    JournalF A S E B Journal
    Volume30
    Issue numberNo. 1 Supplement
    Number of pages1
    ISSN0892-6638
    Publication statusPublished - 2016
    EventExperimental Biology 2016 Meeting: Transforming the future through science - San Diego, United States
    Duration: 2 Apr 2016 → 6 Apr 2016
    http://experimentalbiology.org/2016/home.aspx

    Conference

    ConferenceExperimental Biology 2016 Meeting
    Country/TerritoryUnited States
    CitySan Diego
    Period02/04/2016 → 06/04/2016
    Internet address

    UN SDGs

    This output contributes to the following UN Sustainable Development Goals (SDGs)

    1. SDG 3 - Good Health and Well-being
      SDG 3 Good Health and Well-being

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