Oxygen metabolic competition in the lactic acidotic diabetic kidney: A point of no return?

Christoffer Laustsen, Hans Kasper Wigh Lipsø, Jakob Appel Østergaard, Per Mose Nielsen, Allan Flyvbjerg, Michael Pedersen, Fredrik Palm, Jan Henrik Ardenkjær-Larsen

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Abstract

Diabetic nephropathy is directly related to renal hypoxia, with an increased mitochondrial uncoupling and increased energy demand to maintain normal renal function. Lowering the oxygen content in inspired air has shown to worsen the prognostic outcome of diabetic patients independent of glycemic control. We therefore tested the hypothesis that acutely altered renal oxygen availability alters metabolic pathways related to cellular energy production.
Original languageEnglish
Article number740.7
JournalF A S E B Journal
Volume30
Issue numberNo. 1 Supplement
Number of pages1
ISSN0892-6638
Publication statusPublished - 2016
EventExperimental biology 2016 - San Diego, United States
Duration: 2 Apr 20166 Apr 2016

Conference

ConferenceExperimental biology 2016
CountryUnited States
CitySan Diego
Period02/04/201606/04/2016

Cite this

Laustsen, C., Lipsø, H. K. W., Østergaard, J. A., Nielsen, P. M., Flyvbjerg, A., Pedersen, M., Palm, F., & Ardenkjær-Larsen, J. H. (2016). Oxygen metabolic competition in the lactic acidotic diabetic kidney: A point of no return? F A S E B Journal, 30(No. 1 Supplement), [740.7]. http://www.fasebj.org/content/30/1_Supplement/740.7.short