Oxidative stability of Liposomes composed of docosahexaenoic acid-containing phospholipids

Anders Falk Vikbjerg; Thomas Lars Andresen; Kent Jørgensen; Huiling Mu; Xuebing Xu

doi:10.1007/s11746-007-1086-9

Oxidative stability of Liposomes composed of docosahexaenoic acid-containing phospholipids

Anders Falk Vikbjerg
, Thomas Lars Andresen
, Kent Jørgensen
, Huiling Mu
, Xuebing Xu

Research output: Contribution to journal › Journal article › Research › peer-review

Abstract

Oxidative stability of liposomes made of (Docosahexaenoic acid) DHA-containing phosphatidylcholine (PC) was examined during preparation and storage. After preparation of the liposomes, the concentration of primary (conjugated dienes) and secondary oxidation products (Thiobarbituric acid-reactive substances, TBARS) were significantly higher compared to the initial value. During cold storage, formation of conjugated dienes and TBARS remained more or less constant in large unilamellar vesicles (LUV), whereas in mulitilamellar vesicles (MLV) they were seen to increase over a period of 21 days. Evaporation of solvent traces from a lipid film should preferably be done under nitrogen as vacuum evaporation was found to increase oxidation of the phospholipid.

Original language	English
Journal	JAOCS, Journal of the American Oil Chemists' Society
Volume	84
Issue number	7
Pages (from-to)	631-637
ISSN	0003-021X
DOIs	https://doi.org/10.1007/s11746-007-1086-9
Publication status	Published - 2007

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@article{e71f148b1a8b469bbf5c3bc97e71c3ec,

title = "Oxidative stability of Liposomes composed of docosahexaenoic acid-containing phospholipids",

abstract = "Oxidative stability of liposomes made of (Docosahexaenoic acid) DHA-containing phosphatidylcholine (PC) was examined during preparation and storage. After preparation of the liposomes, the concentration of primary (conjugated dienes) and secondary oxidation products (Thiobarbituric acid-reactive substances, TBARS) were significantly higher compared to the initial value. During cold storage, formation of conjugated dienes and TBARS remained more or less constant in large unilamellar vesicles (LUV), whereas in mulitilamellar vesicles (MLV) they were seen to increase over a period of 21 days. Evaporation of solvent traces from a lipid film should preferably be done under nitrogen as vacuum evaporation was found to increase oxidation of the phospholipid.",

author = "Vikbjerg, \{Anders Falk\} and Andresen, \{Thomas Lars\} and Kent J{\o}rgensen and Huiling Mu and Xuebing Xu",

year = "2007",

doi = "10.1007/s11746-007-1086-9",

language = "English",

volume = "84",

pages = "631--637",

journal = "JAOCS, Journal of the American Oil Chemists' Society",

issn = "0003-021X",

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TY - JOUR

T1 - Oxidative stability of Liposomes composed of docosahexaenoic acid-containing phospholipids

AU - Vikbjerg, Anders Falk

AU - Andresen, Thomas Lars

AU - Jørgensen, Kent

AU - Mu, Huiling

AU - Xu, Xuebing

PY - 2007

Y1 - 2007

N2 - Oxidative stability of liposomes made of (Docosahexaenoic acid) DHA-containing phosphatidylcholine (PC) was examined during preparation and storage. After preparation of the liposomes, the concentration of primary (conjugated dienes) and secondary oxidation products (Thiobarbituric acid-reactive substances, TBARS) were significantly higher compared to the initial value. During cold storage, formation of conjugated dienes and TBARS remained more or less constant in large unilamellar vesicles (LUV), whereas in mulitilamellar vesicles (MLV) they were seen to increase over a period of 21 days. Evaporation of solvent traces from a lipid film should preferably be done under nitrogen as vacuum evaporation was found to increase oxidation of the phospholipid.

AB - Oxidative stability of liposomes made of (Docosahexaenoic acid) DHA-containing phosphatidylcholine (PC) was examined during preparation and storage. After preparation of the liposomes, the concentration of primary (conjugated dienes) and secondary oxidation products (Thiobarbituric acid-reactive substances, TBARS) were significantly higher compared to the initial value. During cold storage, formation of conjugated dienes and TBARS remained more or less constant in large unilamellar vesicles (LUV), whereas in mulitilamellar vesicles (MLV) they were seen to increase over a period of 21 days. Evaporation of solvent traces from a lipid film should preferably be done under nitrogen as vacuum evaporation was found to increase oxidation of the phospholipid.

U2 - 10.1007/s11746-007-1086-9

DO - 10.1007/s11746-007-1086-9

M3 - Journal article

SN - 0003-021X

VL - 84

SP - 631

EP - 637

JO - JAOCS, Journal of the American Oil Chemists' Society

JF - JAOCS, Journal of the American Oil Chemists' Society

IS - 7

ER -

Oxidative stability of Liposomes composed of docosahexaenoic acid-containing phospholipids

Abstract

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