Oxidative stability of Liposomes composed of docosahexaenoic acid-containing phospholipids

Anders Falk Vikbjerg, Thomas Lars Andresen, Kent Jørgensen, Huiling Mu, Xuebing Xu

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

Oxidative stability of liposomes made of (Docosahexaenoic acid) DHA-containing phosphatidylcholine (PC) was examined during preparation and storage. After preparation of the liposomes, the concentration of primary (conjugated dienes) and secondary oxidation products (Thiobarbituric acid-reactive substances, TBARS) were significantly higher compared to the initial value. During cold storage, formation of conjugated dienes and TBARS remained more or less constant in large unilamellar vesicles (LUV), whereas in mulitilamellar vesicles (MLV) they were seen to increase over a period of 21 days. Evaporation of solvent traces from a lipid film should preferably be done under nitrogen as vacuum evaporation was found to increase oxidation of the phospholipid.
Original languageEnglish
JournalJ A O C S
Volume84
Issue number7
Pages (from-to)631-637
ISSN0003-021X
DOIs
Publication statusPublished - 2007

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