Oxidative cyclization of prodigiosin by an alkylglycerol monooxygenase-like enzyme

Tristan de Rond, Parker Stow, Ian Eigl, Rebecca E. Johnson, Leanne Jade G. Chan, Garima Goyal, Edward E. K. Baidoo, Nathan J. Hillson, Christopher J. Petzold, Richmond Sarpong, Jay D. Keasling

Research output: Contribution to journalJournal articleResearchpeer-review

248 Downloads (Pure)

Abstract

Prodiginines, which are tripyrrole alkaloids displaying a wide array of bioactivities, occur as linear and cyclic congeners. Identification of an unclustered biosynthetic gene led to the discovery of the enzyme responsible for catalyzing the regiospecific C–H activation and cyclization of prodigiosin to cycloprodigiosin in Pseudoalteromonas rubra. This enzyme is related to alkylglycerol monooxygenase and unrelated to RedG, the Rieske oxygenase that produces cyclized prodiginines in Streptomyces, implying convergent evolution.
Original languageEnglish
JournalNature Chemical Biology
Volume13
Issue number11
Pages (from-to)1155-1157
ISSN1552-4450
DOIs
Publication statusPublished - 2017

Fingerprint Dive into the research topics of 'Oxidative cyclization of prodigiosin by an alkylglycerol monooxygenase-like enzyme'. Together they form a unique fingerprint.

Cite this