Oxidative cyclization of prodigiosin by an alkylglycerol monooxygenase-like enzyme

Tristan de Rond, Parker Stow, Ian Eigl, Rebecca E. Johnson, Leanne Jade G. Chan, Garima Goyal, Edward E. K. Baidoo, Nathan J. Hillson, Christopher J. Petzold, Richmond Sarpong, Jay D. Keasling

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Prodiginines, which are tripyrrole alkaloids displaying a wide array of bioactivities, occur as linear and cyclic congeners. Identification of an unclustered biosynthetic gene led to the discovery of the enzyme responsible for catalyzing the regiospecific C–H activation and cyclization of prodigiosin to cycloprodigiosin in Pseudoalteromonas rubra. This enzyme is related to alkylglycerol monooxygenase and unrelated to RedG, the Rieske oxygenase that produces cyclized prodiginines in Streptomyces, implying convergent evolution.
Original languageEnglish
JournalNature Chemical Biology
Issue number11
Pages (from-to)1155-1157
Publication statusPublished - 2017


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