Oxepinamides L and M, two new oxepine-pyrimidinone-ketopiperazine type nonribosomal peptides from Aspergillus californicus

Yaojie Guo, Simone Ghidinelli, Mercedes de la Cruz, Thomas A. Mackenzie, Maria C. Ramos, Pilar Sánchez, Francisca Vicente, Olga Genilloud, Thomas O. Larsen*

*Corresponding author for this work

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

A chemical investigation of Aspergillus californicus IBT 16748 led to the isolation of two new oxepine-pyrimidinone-ketopiperazine type nonribosomal peptides oxepinamides L (1) and M (2). Their structures were characterised by spectroscopic analysis including HRESIMS, 1D and 2D NMR. The absolute structure of 1 was assigned by ECD calculation. The antibacterial and cytotoxic properties of 1 were evaluated.
Original languageEnglish
JournalNatural Product Research
Number of pages6
ISSN1478-6419
DOIs
Publication statusAccepted/In press - 2020

Keywords

  • Aspergillus californicus
  • Oxepine
  • Nonribosomal peptides
  • Oxepinamide

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