Overview of in vivo and ex vivo endpoints in murine food allergy models: Suitable for evaluation of the sensitizing capacity of novel proteins?

Laure Castan, Katrine Lindholm Bøgh, Natalia Zofia Maryniak, Michelle M Epstein, Sahar Kazemi, Liam O'Mahony, Marie Bodinier, Joost J Smit, Jolanda H M van Bilsen, Carine Blanchard, Robert Głogowski, Hana Kozáková, Martin Schwarzer, Mario Noti, Nicole de Wit, Grégory Bouchaud, Shanna Bastiaan-Net*

*Corresponding author for this work

Research output: Contribution to journalJournal articleResearchpeer-review

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Abstract

Significant efforts are necessary to introduce new dietary protein sources to feed a growing world population while maintaining food supply chain sustainability. Such a sustainable protein transition includes the use of highly modified proteins from side streams or the introduction of new protein sources that may lead to increased clinically relevant allergic sensitization. With food allergy being a major health problem of increasing concern, understanding the potential allergenicity of new or modified proteins is crucial to ensure public health protection. The best predictive risk assessment methods currently relied on are in vivo models, making the choice of endpoint parameters a key element in evaluating the sensitizing capacity of novel proteins. Here, we provide a comprehensive overview of the most frequently used in vivo and ex vivo endpoints in murine food allergy models, addressing their strengths and limitations for assessing sensitization risks. For optimal laboratory-to-laboratory reproducibility and reliable use of predictive tests for protein risk assessment, it is important that researchers maintain and apply the same relevant parameters and procedures. Thus, there is an urgent need for a consensus on key food allergy parameters to be applied in future food allergy research in synergy between both knowledge institutes and clinicians.
Original languageEnglish
JournalAllergy
Number of pages13
ISSN0105-4538
DOIs
Publication statusAccepted/In press - 2019

Keywords

  • animal models
  • biomarkers
  • food allergy
  • prevention

Cite this

Castan, Laure ; Bøgh, Katrine Lindholm ; Maryniak, Natalia Zofia ; Epstein, Michelle M ; Kazemi, Sahar ; O'Mahony, Liam ; Bodinier, Marie ; Smit, Joost J ; van Bilsen, Jolanda H M ; Blanchard, Carine ; Głogowski, Robert ; Kozáková, Hana ; Schwarzer, Martin ; Noti, Mario ; de Wit, Nicole ; Bouchaud, Grégory ; Bastiaan-Net, Shanna. / Overview of in vivo and ex vivo endpoints in murine food allergy models: Suitable for evaluation of the sensitizing capacity of novel proteins?. In: Allergy. 2019.
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title = "Overview of in vivo and ex vivo endpoints in murine food allergy models: Suitable for evaluation of the sensitizing capacity of novel proteins?",
abstract = "Significant efforts are necessary to introduce new dietary protein sources to feed a growing world population while maintaining food supply chain sustainability. Such a sustainable protein transition includes the use of highly modified proteins from side streams or the introduction of new protein sources that may lead to increased clinically relevant allergic sensitization. With food allergy being a major health problem of increasing concern, understanding the potential allergenicity of new or modified proteins is crucial to ensure public health protection. The best predictive risk assessment methods currently relied on are in vivo models, making the choice of endpoint parameters a key element in evaluating the sensitizing capacity of novel proteins. Here, we provide a comprehensive overview of the most frequently used in vivo and ex vivo endpoints in murine food allergy models, addressing their strengths and limitations for assessing sensitization risks. For optimal laboratory-to-laboratory reproducibility and reliable use of predictive tests for protein risk assessment, it is important that researchers maintain and apply the same relevant parameters and procedures. Thus, there is an urgent need for a consensus on key food allergy parameters to be applied in future food allergy research in synergy between both knowledge institutes and clinicians.",
keywords = "animal models, biomarkers, food allergy, prevention",
author = "Laure Castan and B{\o}gh, {Katrine Lindholm} and Maryniak, {Natalia Zofia} and Epstein, {Michelle M} and Sahar Kazemi and Liam O'Mahony and Marie Bodinier and Smit, {Joost J} and {van Bilsen}, {Jolanda H M} and Carine Blanchard and Robert Głogowski and Hana Koz{\'a}kov{\'a} and Martin Schwarzer and Mario Noti and {de Wit}, Nicole and Gr{\'e}gory Bouchaud and Shanna Bastiaan-Net",
year = "2019",
doi = "10.1111/all.13943",
language = "English",
journal = "Allergy: European Journal of Allergy and Clinical Immunology",
issn = "0105-4538",
publisher = "Wiley Online",

}

Castan, L, Bøgh, KL, Maryniak, NZ, Epstein, MM, Kazemi, S, O'Mahony, L, Bodinier, M, Smit, JJ, van Bilsen, JHM, Blanchard, C, Głogowski, R, Kozáková, H, Schwarzer, M, Noti, M, de Wit, N, Bouchaud, G & Bastiaan-Net, S 2019, 'Overview of in vivo and ex vivo endpoints in murine food allergy models: Suitable for evaluation of the sensitizing capacity of novel proteins?', Allergy. https://doi.org/10.1111/all.13943

Overview of in vivo and ex vivo endpoints in murine food allergy models: Suitable for evaluation of the sensitizing capacity of novel proteins? / Castan, Laure; Bøgh, Katrine Lindholm; Maryniak, Natalia Zofia; Epstein, Michelle M; Kazemi, Sahar; O'Mahony, Liam; Bodinier, Marie; Smit, Joost J; van Bilsen, Jolanda H M; Blanchard, Carine; Głogowski, Robert; Kozáková, Hana; Schwarzer, Martin; Noti, Mario; de Wit, Nicole; Bouchaud, Grégory; Bastiaan-Net, Shanna.

In: Allergy, 2019.

Research output: Contribution to journalJournal articleResearchpeer-review

TY - JOUR

T1 - Overview of in vivo and ex vivo endpoints in murine food allergy models: Suitable for evaluation of the sensitizing capacity of novel proteins?

AU - Castan, Laure

AU - Bøgh, Katrine Lindholm

AU - Maryniak, Natalia Zofia

AU - Epstein, Michelle M

AU - Kazemi, Sahar

AU - O'Mahony, Liam

AU - Bodinier, Marie

AU - Smit, Joost J

AU - van Bilsen, Jolanda H M

AU - Blanchard, Carine

AU - Głogowski, Robert

AU - Kozáková, Hana

AU - Schwarzer, Martin

AU - Noti, Mario

AU - de Wit, Nicole

AU - Bouchaud, Grégory

AU - Bastiaan-Net, Shanna

PY - 2019

Y1 - 2019

N2 - Significant efforts are necessary to introduce new dietary protein sources to feed a growing world population while maintaining food supply chain sustainability. Such a sustainable protein transition includes the use of highly modified proteins from side streams or the introduction of new protein sources that may lead to increased clinically relevant allergic sensitization. With food allergy being a major health problem of increasing concern, understanding the potential allergenicity of new or modified proteins is crucial to ensure public health protection. The best predictive risk assessment methods currently relied on are in vivo models, making the choice of endpoint parameters a key element in evaluating the sensitizing capacity of novel proteins. Here, we provide a comprehensive overview of the most frequently used in vivo and ex vivo endpoints in murine food allergy models, addressing their strengths and limitations for assessing sensitization risks. For optimal laboratory-to-laboratory reproducibility and reliable use of predictive tests for protein risk assessment, it is important that researchers maintain and apply the same relevant parameters and procedures. Thus, there is an urgent need for a consensus on key food allergy parameters to be applied in future food allergy research in synergy between both knowledge institutes and clinicians.

AB - Significant efforts are necessary to introduce new dietary protein sources to feed a growing world population while maintaining food supply chain sustainability. Such a sustainable protein transition includes the use of highly modified proteins from side streams or the introduction of new protein sources that may lead to increased clinically relevant allergic sensitization. With food allergy being a major health problem of increasing concern, understanding the potential allergenicity of new or modified proteins is crucial to ensure public health protection. The best predictive risk assessment methods currently relied on are in vivo models, making the choice of endpoint parameters a key element in evaluating the sensitizing capacity of novel proteins. Here, we provide a comprehensive overview of the most frequently used in vivo and ex vivo endpoints in murine food allergy models, addressing their strengths and limitations for assessing sensitization risks. For optimal laboratory-to-laboratory reproducibility and reliable use of predictive tests for protein risk assessment, it is important that researchers maintain and apply the same relevant parameters and procedures. Thus, there is an urgent need for a consensus on key food allergy parameters to be applied in future food allergy research in synergy between both knowledge institutes and clinicians.

KW - animal models

KW - biomarkers

KW - food allergy

KW - prevention

U2 - 10.1111/all.13943

DO - 10.1111/all.13943

M3 - Journal article

JO - Allergy: European Journal of Allergy and Clinical Immunology

JF - Allergy: European Journal of Allergy and Clinical Immunology

SN - 0105-4538

ER -