Overnight Control of Blood Glucose in People with Type 1 Diabetes

Dimitri Boiroux; Anne Katrine Duun-Henriksen; Signe Schmidt; Kirsten Nørgaard; Sten Madsbad; Ole Skyggebjerg; Peter Ruhdal Jensen; Niels Kjølstad Poulsen; Henrik Madsen; John Bagterp Jørgensen

doi:10.3182/20120829-3-HU-2029.00106

Overnight Control of Blood Glucose in People with Type 1 Diabetes

Dimitri Boiroux
, Anne Katrine Duun-Henriksen
, Signe Schmidt
, Kirsten Nørgaard
, Sten Madsbad
, Ole Skyggebjerg
, Peter Ruhdal Jensen
, Niels Kjølstad Poulsen
, Henrik Madsen
, John Bagterp Jørgensen

Center for Energy Resources Engineering

Horus ApS
Copenhagen University Hospital Herlev and Gentofte

Research output: Chapter in Book/Report/Conference proceeding › Article in proceedings › Research › peer-review

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Abstract

In this paper, we develop and test a Model Predictive Controller (MPC) for overnight stabilization of blood glucose in people with type 1 diabetes. The controller uses glucose measurements from a continuous glucose monitor (CGM) and its decisions are implemented by a continuous subcutaneous insulin infusion (CSII) pump. Based on a priori patient information, we propose a systematic method for computation of the model parameters in the MPC. Safety layers improve the controller robustness and reduce the risk of hypoglycemia. The controller is evaluated in silico on a cohort of 100 randomly generated patients with a representative intersubject variability. This cohort is simulated overnight with realistic variations in the insulin sensitivities and needs. Finally, we provide results for the first tests of this controller in a real clinic.

Original language	English
Title of host publication	Biological and Medical Systems
Volume	8
Publication date	2012
Pages	73-78
ISBN (Print)	978-3-902823-10-6
DOIs	https://doi.org/10.3182/20120829-3-HU-2029.00106
Publication status	Published - 2012
Event	8th IFAC Symposium on Biological and Medical Systems - Budapest, Hungary Duration: 29 Aug 2012 → 31 Aug 2012 http://bms.iit.bme.hu/

Conference

Conference	8th IFAC Symposium on Biological and Medical Systems
Country/Territory	Hungary
City	Budapest
Period	29/08/2012 → 31/08/2012
Internet address	http://bms.iit.bme.hu/

Series	IFAC Proceedings Volumes (IFAC-PapersOnline)

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

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10.3182/20120829-3-HU-2029.00106

Boiroux BMS2012 0106 FI

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@inproceedings{d67d642e00f049ce88884925fd8f8df3,

title = "Overnight Control of Blood Glucose in People with Type 1 Diabetes",

abstract = "In this paper, we develop and test a Model Predictive Controller (MPC) for overnight stabilization of blood glucose in people with type 1 diabetes. The controller uses glucose measurements from a continuous glucose monitor (CGM) and its decisions are implemented by a continuous subcutaneous insulin infusion (CSII) pump. Based on a priori patient information, we propose a systematic method for computation of the model parameters in the MPC. Safety layers improve the controller robustness and reduce the risk of hypoglycemia. The controller is evaluated in silico on a cohort of 100 randomly generated patients with a representative intersubject variability. This cohort is simulated overnight with realistic variations in the insulin sensitivities and needs. Finally, we provide results for the first tests of this controller in a real clinic.",

author = "Dimitri Boiroux and Duun-Henriksen, \{Anne Katrine\} and Signe Schmidt and Kirsten N{\o}rgaard and Sten Madsbad and Ole Skyggebjerg and Jensen, \{Peter Ruhdal\} and Poulsen, \{Niels Kj{\o}lstad\} and Henrik Madsen and J{\o}rgensen, \{John Bagterp\}",

year = "2012",

doi = "10.3182/20120829-3-HU-2029.00106",

language = "English",

isbn = "978-3-902823-10-6",

volume = "8",

series = "IFAC Proceedings Volumes (IFAC-PapersOnline) ",

publisher = "International Federation of Automatic Control",

pages = "73--78",

booktitle = "Biological and Medical Systems",

note = "8th IFAC Symposium on Biological and Medical Systems ; Conference date: 29-08-2012 Through 31-08-2012",

url = "http://bms.iit.bme.hu/",

}

Boiroux, D, Duun-Henriksen, AK, Schmidt, S, Nørgaard, K, Madsbad, S, Skyggebjerg, O, Jensen, PR, Poulsen, NK, Madsen, H & Jørgensen, JB 2012, Overnight Control of Blood Glucose in People with Type 1 Diabetes. in Biological and Medical Systems. vol. 8, IFAC Proceedings Volumes (IFAC-PapersOnline) , pp. 73-78, 8th IFAC Symposium on Biological and Medical Systems, Budapest, Hungary, 29/08/2012. https://doi.org/10.3182/20120829-3-HU-2029.00106

TY - GEN

T1 - Overnight Control of Blood Glucose in People with Type 1 Diabetes

AU - Boiroux, Dimitri

AU - Duun-Henriksen, Anne Katrine

AU - Schmidt, Signe

AU - Nørgaard, Kirsten

AU - Madsbad, Sten

AU - Skyggebjerg, Ole

AU - Jensen, Peter Ruhdal

AU - Poulsen, Niels Kjølstad

AU - Madsen, Henrik

AU - Jørgensen, John Bagterp

PY - 2012

Y1 - 2012

N2 - In this paper, we develop and test a Model Predictive Controller (MPC) for overnight stabilization of blood glucose in people with type 1 diabetes. The controller uses glucose measurements from a continuous glucose monitor (CGM) and its decisions are implemented by a continuous subcutaneous insulin infusion (CSII) pump. Based on a priori patient information, we propose a systematic method for computation of the model parameters in the MPC. Safety layers improve the controller robustness and reduce the risk of hypoglycemia. The controller is evaluated in silico on a cohort of 100 randomly generated patients with a representative intersubject variability. This cohort is simulated overnight with realistic variations in the insulin sensitivities and needs. Finally, we provide results for the first tests of this controller in a real clinic.

AB - In this paper, we develop and test a Model Predictive Controller (MPC) for overnight stabilization of blood glucose in people with type 1 diabetes. The controller uses glucose measurements from a continuous glucose monitor (CGM) and its decisions are implemented by a continuous subcutaneous insulin infusion (CSII) pump. Based on a priori patient information, we propose a systematic method for computation of the model parameters in the MPC. Safety layers improve the controller robustness and reduce the risk of hypoglycemia. The controller is evaluated in silico on a cohort of 100 randomly generated patients with a representative intersubject variability. This cohort is simulated overnight with realistic variations in the insulin sensitivities and needs. Finally, we provide results for the first tests of this controller in a real clinic.

U2 - 10.3182/20120829-3-HU-2029.00106

DO - 10.3182/20120829-3-HU-2029.00106

M3 - Article in proceedings

SN - 978-3-902823-10-6

VL - 8

T3 - IFAC Proceedings Volumes (IFAC-PapersOnline)

SP - 73

EP - 78

BT - Biological and Medical Systems

T2 - 8th IFAC Symposium on Biological and Medical Systems

Y2 - 29 August 2012 through 31 August 2012

ER -

Overnight Control of Blood Glucose in People with Type 1 Diabetes

Abstract

Conference

UN SDGs

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