Overnight Control of Blood Glucose in People with Type 1 Diabetes

Dimitri Boiroux; Anne Katrine Duun-Henriksen; Signe Schmidt; Kirsten Nørgaard; Sten Madsbad; Ole Skyggebjerg; Peter Ruhdal Jensen; Niels Kjølstad Poulsen; Henrik Madsen; John Bagterp Jørgensen

doi:10.3182/20120829-3-HU-2029.00106

Overnight Control of Blood Glucose in People with Type 1 Diabetes

Dimitri Boiroux, Anne Katrine Duun-Henriksen, Signe Schmidt, Kirsten Nørgaard, Sten Madsbad, Ole Skyggebjerg, Peter Ruhdal Jensen, Niels Kjølstad Poulsen, Henrik Madsen, John Bagterp Jørgensen

Center for Energy Resources Engineering

Research output: Chapter in Book/Report/Conference proceeding › Article in proceedings › Research › peer-review

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Abstract

In this paper, we develop and test a Model Predictive Controller (MPC) for overnight stabilization of blood glucose in people with type 1 diabetes. The controller uses glucose measurements from a continuous glucose monitor (CGM) and its decisions are implemented by a continuous subcutaneous insulin infusion (CSII) pump. Based on a priori patient information, we propose a systematic method for computation of the model parameters in the MPC. Safety layers improve the controller robustness and reduce the risk of hypoglycemia. The controller is evaluated in silico on a cohort of 100 randomly generated patients with a representative intersubject variability. This cohort is simulated overnight with realistic variations in the insulin sensitivities and needs. Finally, we provide results for the first tests of this controller in a real clinic.

Original language	English
Title of host publication	Biological and Medical Systems
Volume	8
Publication date	2012
Pages	73-78
ISBN (Print)	978-3-902823-10-6
DOIs	https://doi.org/10.3182/20120829-3-HU-2029.00106
Publication status	Published - 2012
Event	8th IFAC Symposium on Biological and Medical Systems - Budapest, Hungary Duration: 29 Aug 2012 → 31 Aug 2012 http://bms.iit.bme.hu/

Conference

Conference	8th IFAC Symposium on Biological and Medical Systems
Country/Territory	Hungary
City	Budapest
Period	29/08/2012 → 31/08/2012
Internet address	http://bms.iit.bme.hu/

Series	IFAC Proceedings Volumes (IFAC-PapersOnline)

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Boiroux, D., Duun-Henriksen, A. K., Schmidt, S., Nørgaard, K., Madsbad, S., Skyggebjerg, O., Jensen, P. R., Poulsen, N. K., Madsen, H., & Jørgensen, J. B. (2012). Overnight Control of Blood Glucose in People with Type 1 Diabetes. In Biological and Medical Systems (Vol. 8, pp. 73-78). IFAC Proceedings Volumes (IFAC-PapersOnline) https://doi.org/10.3182/20120829-3-HU-2029.00106

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title = "Overnight Control of Blood Glucose in People with Type 1 Diabetes",

abstract = "In this paper, we develop and test a Model Predictive Controller (MPC) for overnight stabilization of blood glucose in people with type 1 diabetes. The controller uses glucose measurements from a continuous glucose monitor (CGM) and its decisions are implemented by a continuous subcutaneous insulin infusion (CSII) pump. Based on a priori patient information, we propose a systematic method for computation of the model parameters in the MPC. Safety layers improve the controller robustness and reduce the risk of hypoglycemia. The controller is evaluated in silico on a cohort of 100 randomly generated patients with a representative intersubject variability. This cohort is simulated overnight with realistic variations in the insulin sensitivities and needs. Finally, we provide results for the first tests of this controller in a real clinic.",

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publisher = "International Federation of Automatic Control",

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note = "8th IFAC Symposium on Biological and Medical Systems ; Conference date: 29-08-2012 Through 31-08-2012",

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Boiroux, D, Duun-Henriksen, AK, Schmidt, S, Nørgaard, K, Madsbad, S, Skyggebjerg, O, Jensen, PR , Poulsen, NK , Madsen, H & Jørgensen, JB 2012, Overnight Control of Blood Glucose in People with Type 1 Diabetes. in Biological and Medical Systems. vol. 8, IFAC Proceedings Volumes (IFAC-PapersOnline) , pp. 73-78, 8th IFAC Symposium on Biological and Medical Systems, Budapest, Hungary, 29/08/2012. https://doi.org/10.3182/20120829-3-HU-2029.00106

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AU - Skyggebjerg, Ole

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Overnight Control of Blood Glucose in People with Type 1 Diabetes

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