Overnight Control of Blood Glucose in People with Type 1 Diabetes

Dimitri Boiroux, Anne Katrine Duun-Henriksen, Signe Schmidt, Kirsten Nørgaard, Sten Madsbad, Ole Skyggebjerg, Peter Ruhdal Jensen, Niels Kjølstad Poulsen, Henrik Madsen, John Bagterp Jørgensen

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In this paper, we develop and test a Model Predictive Controller (MPC) for overnight stabilization of blood glucose in people with type 1 diabetes. The controller uses glucose measurements from a continuous glucose monitor (CGM) and its decisions are implemented by a continuous subcutaneous insulin infusion (CSII) pump. Based on a priori patient information, we propose a systematic method for computation of the model parameters in the MPC. Safety layers improve the controller robustness and reduce the risk of hypoglycemia. The controller is evaluated in silico on a cohort of 100 randomly generated patients with a representative intersubject variability. This cohort is simulated overnight with realistic variations in the insulin sensitivities and needs. Finally, we provide results for the first tests of this controller in a real clinic.
Original languageEnglish
Title of host publicationBiological and Medical Systems
Publication date2012
ISBN (Print)978-3-902823-10-6
Publication statusPublished - 2012
Event8th IFAC Symposium on Biological and Medical Systems - Budapest, Hungary
Duration: 29 Aug 201231 Aug 2012


Conference8th IFAC Symposium on Biological and Medical Systems
Internet address
SeriesIFAC Proceedings Volumes (IFAC-PapersOnline)

Cite this

Boiroux, D., Duun-Henriksen, A. K., Schmidt, S., Nørgaard, K., Madsbad, S., Skyggebjerg, O., Jensen, P. R., Poulsen, N. K., Madsen, H., & Jørgensen, J. B. (2012). Overnight Control of Blood Glucose in People with Type 1 Diabetes. In Biological and Medical Systems (Vol. 8, pp. 73-78). IFAC Proceedings Volumes (IFAC-PapersOnline) https://doi.org/10.3182/20120829-3-HU-2029.00106