Overhauser enhanced magnetic resonance imaging for tumor oximetry: Coregistration of tumor anatomy and tissue oxygen concentration

Murali C. Krishna, Sean English, Kenichi Yamada, John Yoo, Ramachandran Murugesan, Nallathamby Devasahayam, John A. Cook, Klaes Golman, Jan Henrik Ardenkjaer-Larsen, Sankaran Subramanian, James B. Mitchell

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

An efficient noninvasive method for in vivo imaging of tumor oxygenation by using a low-field magnetic resonance scanner and a paramagnetic contrast agent is described. The methodology is based on Overhauser enhanced magnetic resonance imaging (OMRI), a functional imaging technique. OMRI experiments were performed on tumor-bearing mice (squamous cell carcinoma) by i.v. administration of the contrast agent Oxo63 (a highly derivatized triarylmethyl radical) at nontoxic doses in the range of 2-7 mmol/kg either as a bolus or as a continuous infusion. Spatially resolved pO2 (oxygen concentration) images from OMRI experiments of tumor-bearing mice exhibited heterogeneous oxygenation profiles and revealed regions of hypoxia in tumors (
Original languageEnglish
JournalProceedings of the National Academy of Sciences of the United States of America
Volume99
Issue number4
Pages (from-to)2216-2221
ISSN0027-8424
DOIs
Publication statusPublished - 2002
Externally publishedYes

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