Overhauser enhanced magnetic resonance imaging for tumor oximetry: Coregistration of tumor anatomy and tissue oxygen concentration

Murali C. Krishna; Sean English; Kenichi Yamada; John Yoo; Ramachandran Murugesan; Nallathamby Devasahayam; John A. Cook; Klaes Golman; Jan Henrik Ardenkjaer-Larsen; Sankaran Subramanian; James B. Mitchell

doi:10.1073/pnas.042671399

Overhauser enhanced magnetic resonance imaging for tumor oximetry: Coregistration of tumor anatomy and tissue oxygen concentration

Murali C. Krishna, Sean English, Kenichi Yamada, John Yoo, Ramachandran Murugesan, Nallathamby Devasahayam, John A. Cook, Klaes Golman, Jan Henrik Ardenkjaer-Larsen, Sankaran Subramanian, James B. Mitchell

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Abstract

An efficient noninvasive method for in vivo imaging of tumor oxygenation by using a low-field magnetic resonance scanner and a paramagnetic contrast agent is described. The methodology is based on Overhauser enhanced magnetic resonance imaging (OMRI), a functional imaging technique. OMRI experiments were performed on tumor-bearing mice (squamous cell carcinoma) by i.v. administration of the contrast agent Oxo63 (a highly derivatized triarylmethyl radical) at nontoxic doses in the range of 2-7 mmol/kg either as a bolus or as a continuous infusion. Spatially resolved pO2 (oxygen concentration) images from OMRI experiments of tumor-bearing mice exhibited heterogeneous oxygenation profiles and revealed regions of hypoxia in tumors (

Original language	English
Journal	Proceedings of the National Academy of Sciences of the United States of America
Volume	99
Issue number	4
Pages (from-to)	2216-2221
ISSN	0027-8424
DOIs	https://doi.org/10.1073/pnas.042671399
Publication status	Published - 2002
Externally published	Yes

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Krishna, M. C., English, S., Yamada, K., Yoo, J., Murugesan, R., Devasahayam, N., Cook, J. A., Golman, K., Ardenkjaer-Larsen, J. H., Subramanian, S., & Mitchell, J. B. (2002). Overhauser enhanced magnetic resonance imaging for tumor oximetry: Coregistration of tumor anatomy and tissue oxygen concentration. Proceedings of the National Academy of Sciences of the United States of America, 99(4), 2216-2221. https://doi.org/10.1073/pnas.042671399

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title = "Overhauser enhanced magnetic resonance imaging for tumor oximetry: Coregistration of tumor anatomy and tissue oxygen concentration",

abstract = "An efficient noninvasive method for in vivo imaging of tumor oxygenation by using a low-field magnetic resonance scanner and a paramagnetic contrast agent is described. The methodology is based on Overhauser enhanced magnetic resonance imaging (OMRI), a functional imaging technique. OMRI experiments were performed on tumor-bearing mice (squamous cell carcinoma) by i.v. administration of the contrast agent Oxo63 (a highly derivatized triarylmethyl radical) at nontoxic doses in the range of 2-7 mmol/kg either as a bolus or as a continuous infusion. Spatially resolved pO2 (oxygen concentration) images from OMRI experiments of tumor-bearing mice exhibited heterogeneous oxygenation profiles and revealed regions of hypoxia in tumors (",

author = "Krishna, {Murali C.} and Sean English and Kenichi Yamada and John Yoo and Ramachandran Murugesan and Nallathamby Devasahayam and Cook, {John A.} and Klaes Golman and Ardenkjaer-Larsen, {Jan Henrik} and Sankaran Subramanian and Mitchell, {James B.}",

year = "2002",

doi = "10.1073/pnas.042671399",

language = "English",

volume = "99",

pages = "2216--2221",

journal = "Proceedings of the National Academy of Sciences of the United States of America",

issn = "0027-8424",

publisher = "The National Academy of Sciences of the United States of America",

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Krishna, MC, English, S, Yamada, K, Yoo, J, Murugesan, R, Devasahayam, N, Cook, JA, Golman, K, Ardenkjaer-Larsen, JH, Subramanian, S & Mitchell, JB 2002, 'Overhauser enhanced magnetic resonance imaging for tumor oximetry: Coregistration of tumor anatomy and tissue oxygen concentration', Proceedings of the National Academy of Sciences of the United States of America, vol. 99, no. 4, pp. 2216-2221. https://doi.org/10.1073/pnas.042671399

Overhauser enhanced magnetic resonance imaging for tumor oximetry: Coregistration of tumor anatomy and tissue oxygen concentration. / Krishna, Murali C.; English, Sean; Yamada, Kenichi et al.
In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 99, No. 4, 2002, p. 2216-2221.

Research output: Contribution to journal › Journal article › Research › peer-review

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T1 - Overhauser enhanced magnetic resonance imaging for tumor oximetry: Coregistration of tumor anatomy and tissue oxygen concentration

AU - Krishna, Murali C.

AU - English, Sean

AU - Yamada, Kenichi

AU - Yoo, John

AU - Murugesan, Ramachandran

AU - Devasahayam, Nallathamby

AU - Cook, John A.

AU - Golman, Klaes

AU - Ardenkjaer-Larsen, Jan Henrik

AU - Subramanian, Sankaran

AU - Mitchell, James B.

PY - 2002

Y1 - 2002

N2 - An efficient noninvasive method for in vivo imaging of tumor oxygenation by using a low-field magnetic resonance scanner and a paramagnetic contrast agent is described. The methodology is based on Overhauser enhanced magnetic resonance imaging (OMRI), a functional imaging technique. OMRI experiments were performed on tumor-bearing mice (squamous cell carcinoma) by i.v. administration of the contrast agent Oxo63 (a highly derivatized triarylmethyl radical) at nontoxic doses in the range of 2-7 mmol/kg either as a bolus or as a continuous infusion. Spatially resolved pO2 (oxygen concentration) images from OMRI experiments of tumor-bearing mice exhibited heterogeneous oxygenation profiles and revealed regions of hypoxia in tumors (

AB - An efficient noninvasive method for in vivo imaging of tumor oxygenation by using a low-field magnetic resonance scanner and a paramagnetic contrast agent is described. The methodology is based on Overhauser enhanced magnetic resonance imaging (OMRI), a functional imaging technique. OMRI experiments were performed on tumor-bearing mice (squamous cell carcinoma) by i.v. administration of the contrast agent Oxo63 (a highly derivatized triarylmethyl radical) at nontoxic doses in the range of 2-7 mmol/kg either as a bolus or as a continuous infusion. Spatially resolved pO2 (oxygen concentration) images from OMRI experiments of tumor-bearing mice exhibited heterogeneous oxygenation profiles and revealed regions of hypoxia in tumors (

U2 - 10.1073/pnas.042671399

DO - 10.1073/pnas.042671399

M3 - Journal article

SN - 0027-8424

VL - 99

SP - 2216

EP - 2221

JO - Proceedings of the National Academy of Sciences of the United States of America

JF - Proceedings of the National Academy of Sciences of the United States of America

IS - 4

ER -

Overhauser enhanced magnetic resonance imaging for tumor oximetry: Coregistration of tumor anatomy and tissue oxygen concentration

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