Outbreaks of influenza of swine and human origin in mink (Neovison vison)

Charlotte Kristiane Hjulsager, Jesper Schak Krog, Mariann Chriél, Gitte Larsen, Lars Erik Larsen

    Research output: Contribution to conferenceConference abstract for conferenceResearchpeer-review

    33 Downloads (Pure)

    Abstract

    Influenza A virus infections in farmed mink, that are associated with respiratory disease, have occasionally been reported from mink producing countries. The viruses isolated have mainly been of avian or swine origin. Infections in mink with seasonal human influenza viruses have been inferred mainly from antibody detections. In 2009, the first outbreak with Influenza A virus was recognized in Danish farmed mink. The virus was a novel reassortant H3N2 virus. The HA and NA genes were most closely related to the 2005/06 human seasonal influenza virus and the internal genes were of contemporary swine influenza virus origin. All the infected farms received feed from the same feed producer. The feed contained fresh swine offal and the outbreak was therefore suspected to be feed-borne.Since 2009, Influenza A viruses have been detected in farmed mink in Denmark almost every year. Outbreaks are typically associated with sneezing, pneumonia and haemolytic E. coli infections. Characteristic is also bleeding from the nose. The mortality varies but is normally between three to five per cent in the affected farms.
    The aim of this study was to elucidate the origin of influenza A viruses detected in Danish farmed mink in recent years by genetic and phylogenetic analyses of influenza A virus genes.The results showed that the viruses involved were either closely related to contemporary swine influenza viruses (avian-like H1N2 or H1N1) or to H1N1pdm09. The 2009 H3N2 virus has not been detected since 2009. The avian-like HA swine H1N1 and H1N2 viruses have never been detected in humans in Denmark, but are the most prevalent subtypes detected in the Danish swine herds with respiratory disease. Thus feed content of swine origin is a likely source of these viruses in mink.
    The H1N1pdm09 viruses have been circulating in Danish swine since 2010 and the same subtype is now considered seasonal influenza virus in humans, rather than being “pandemic”.Genetic analyses showed that some of the H1N1pdm09 viruses found in mink had a higher level of identity to H1N1pdm09 strains detected in humans than in swine. This suggests that these viruses were transmitted directly from humans to mink.
    Original languageEnglish
    Publication date2018
    Number of pages1
    Publication statusPublished - 2018
    Event4th International Symposium on Neglected Influenza Viruses. - Brighton, United Kingdom
    Duration: 18 Apr 201820 Apr 2018

    Conference

    Conference4th International Symposium on Neglected Influenza Viruses.
    CountryUnited Kingdom
    CityBrighton
    Period18/04/201820/04/2018

    Cite this

    Hjulsager, C. K., Krog, J. S., Chriél, M., Larsen, G., & Larsen, L. E. (2018). Outbreaks of influenza of swine and human origin in mink (Neovison vison). Abstract from 4th International Symposium on Neglected Influenza Viruses., Brighton, United Kingdom.
    Hjulsager, Charlotte Kristiane ; Krog, Jesper Schak ; Chriél, Mariann ; Larsen, Gitte ; Larsen, Lars Erik. / Outbreaks of influenza of swine and human origin in mink (Neovison vison). Abstract from 4th International Symposium on Neglected Influenza Viruses., Brighton, United Kingdom.1 p.
    @conference{d7e18d11f0884c4ba8d780c76ea15a53,
    title = "Outbreaks of influenza of swine and human origin in mink (Neovison vison)",
    abstract = "Influenza A virus infections in farmed mink, that are associated with respiratory disease, have occasionally been reported from mink producing countries. The viruses isolated have mainly been of avian or swine origin. Infections in mink with seasonal human influenza viruses have been inferred mainly from antibody detections. In 2009, the first outbreak with Influenza A virus was recognized in Danish farmed mink. The virus was a novel reassortant H3N2 virus. The HA and NA genes were most closely related to the 2005/06 human seasonal influenza virus and the internal genes were of contemporary swine influenza virus origin. All the infected farms received feed from the same feed producer. The feed contained fresh swine offal and the outbreak was therefore suspected to be feed-borne.Since 2009, Influenza A viruses have been detected in farmed mink in Denmark almost every year. Outbreaks are typically associated with sneezing, pneumonia and haemolytic E. coli infections. Characteristic is also bleeding from the nose. The mortality varies but is normally between three to five per cent in the affected farms.The aim of this study was to elucidate the origin of influenza A viruses detected in Danish farmed mink in recent years by genetic and phylogenetic analyses of influenza A virus genes.The results showed that the viruses involved were either closely related to contemporary swine influenza viruses (avian-like H1N2 or H1N1) or to H1N1pdm09. The 2009 H3N2 virus has not been detected since 2009. The avian-like HA swine H1N1 and H1N2 viruses have never been detected in humans in Denmark, but are the most prevalent subtypes detected in the Danish swine herds with respiratory disease. Thus feed content of swine origin is a likely source of these viruses in mink.The H1N1pdm09 viruses have been circulating in Danish swine since 2010 and the same subtype is now considered seasonal influenza virus in humans, rather than being “pandemic”.Genetic analyses showed that some of the H1N1pdm09 viruses found in mink had a higher level of identity to H1N1pdm09 strains detected in humans than in swine. This suggests that these viruses were transmitted directly from humans to mink.",
    author = "Hjulsager, {Charlotte Kristiane} and Krog, {Jesper Schak} and Mariann Chri{\'e}l and Gitte Larsen and Larsen, {Lars Erik}",
    year = "2018",
    language = "English",
    note = "4th International Symposium on Neglected Influenza Viruses. ; Conference date: 18-04-2018 Through 20-04-2018",

    }

    Hjulsager, CK, Krog, JS, Chriél, M, Larsen, G & Larsen, LE 2018, 'Outbreaks of influenza of swine and human origin in mink (Neovison vison)' 4th International Symposium on Neglected Influenza Viruses., Brighton, United Kingdom, 18/04/2018 - 20/04/2018, .

    Outbreaks of influenza of swine and human origin in mink (Neovison vison). / Hjulsager, Charlotte Kristiane; Krog, Jesper Schak; Chriél, Mariann; Larsen, Gitte; Larsen, Lars Erik.

    2018. Abstract from 4th International Symposium on Neglected Influenza Viruses., Brighton, United Kingdom.

    Research output: Contribution to conferenceConference abstract for conferenceResearchpeer-review

    TY - ABST

    T1 - Outbreaks of influenza of swine and human origin in mink (Neovison vison)

    AU - Hjulsager, Charlotte Kristiane

    AU - Krog, Jesper Schak

    AU - Chriél, Mariann

    AU - Larsen, Gitte

    AU - Larsen, Lars Erik

    PY - 2018

    Y1 - 2018

    N2 - Influenza A virus infections in farmed mink, that are associated with respiratory disease, have occasionally been reported from mink producing countries. The viruses isolated have mainly been of avian or swine origin. Infections in mink with seasonal human influenza viruses have been inferred mainly from antibody detections. In 2009, the first outbreak with Influenza A virus was recognized in Danish farmed mink. The virus was a novel reassortant H3N2 virus. The HA and NA genes were most closely related to the 2005/06 human seasonal influenza virus and the internal genes were of contemporary swine influenza virus origin. All the infected farms received feed from the same feed producer. The feed contained fresh swine offal and the outbreak was therefore suspected to be feed-borne.Since 2009, Influenza A viruses have been detected in farmed mink in Denmark almost every year. Outbreaks are typically associated with sneezing, pneumonia and haemolytic E. coli infections. Characteristic is also bleeding from the nose. The mortality varies but is normally between three to five per cent in the affected farms.The aim of this study was to elucidate the origin of influenza A viruses detected in Danish farmed mink in recent years by genetic and phylogenetic analyses of influenza A virus genes.The results showed that the viruses involved were either closely related to contemporary swine influenza viruses (avian-like H1N2 or H1N1) or to H1N1pdm09. The 2009 H3N2 virus has not been detected since 2009. The avian-like HA swine H1N1 and H1N2 viruses have never been detected in humans in Denmark, but are the most prevalent subtypes detected in the Danish swine herds with respiratory disease. Thus feed content of swine origin is a likely source of these viruses in mink.The H1N1pdm09 viruses have been circulating in Danish swine since 2010 and the same subtype is now considered seasonal influenza virus in humans, rather than being “pandemic”.Genetic analyses showed that some of the H1N1pdm09 viruses found in mink had a higher level of identity to H1N1pdm09 strains detected in humans than in swine. This suggests that these viruses were transmitted directly from humans to mink.

    AB - Influenza A virus infections in farmed mink, that are associated with respiratory disease, have occasionally been reported from mink producing countries. The viruses isolated have mainly been of avian or swine origin. Infections in mink with seasonal human influenza viruses have been inferred mainly from antibody detections. In 2009, the first outbreak with Influenza A virus was recognized in Danish farmed mink. The virus was a novel reassortant H3N2 virus. The HA and NA genes were most closely related to the 2005/06 human seasonal influenza virus and the internal genes were of contemporary swine influenza virus origin. All the infected farms received feed from the same feed producer. The feed contained fresh swine offal and the outbreak was therefore suspected to be feed-borne.Since 2009, Influenza A viruses have been detected in farmed mink in Denmark almost every year. Outbreaks are typically associated with sneezing, pneumonia and haemolytic E. coli infections. Characteristic is also bleeding from the nose. The mortality varies but is normally between three to five per cent in the affected farms.The aim of this study was to elucidate the origin of influenza A viruses detected in Danish farmed mink in recent years by genetic and phylogenetic analyses of influenza A virus genes.The results showed that the viruses involved were either closely related to contemporary swine influenza viruses (avian-like H1N2 or H1N1) or to H1N1pdm09. The 2009 H3N2 virus has not been detected since 2009. The avian-like HA swine H1N1 and H1N2 viruses have never been detected in humans in Denmark, but are the most prevalent subtypes detected in the Danish swine herds with respiratory disease. Thus feed content of swine origin is a likely source of these viruses in mink.The H1N1pdm09 viruses have been circulating in Danish swine since 2010 and the same subtype is now considered seasonal influenza virus in humans, rather than being “pandemic”.Genetic analyses showed that some of the H1N1pdm09 viruses found in mink had a higher level of identity to H1N1pdm09 strains detected in humans than in swine. This suggests that these viruses were transmitted directly from humans to mink.

    M3 - Conference abstract for conference

    ER -

    Hjulsager CK, Krog JS, Chriél M, Larsen G, Larsen LE. Outbreaks of influenza of swine and human origin in mink (Neovison vison). 2018. Abstract from 4th International Symposium on Neglected Influenza Viruses., Brighton, United Kingdom.