Outbreaks of influenza A virus in farmed mink (Neovison vison) in Denmark: molecular characterization of the viruses

Lars Erik Larsen, Solvej Østergaard Breum, Ramona Trebbien, K. Bradstad, L. P. Nielsen, Mariann Chriél, Trine Hammer Jensen, Charlotte Kristiane Hjulsager, Kurt Handberg, Poul Henrik Jørgensen, Jakob le Fèvre Harslund, Lena Rangstrup-Christensen, B. Petersen, Anne Sofie Hammer

    Research output: Chapter in Book/Report/Conference proceedingArticle in proceedingsResearchpeer-review

    Abstract

    Influenza in mink (Neovison vison) is assumed to be rare, but several outbreaks have been described during recent years in Europe and the North America. In 2009, influenza A of the subtype H3N2 was detected in several Danish mink farms with respiratory symptoms. Full-genome sequencing showed that the virus was a human/swine reassortant, with the H and N gene most related to human H3N2 viruses circulating in 2005. The remaining 6 genes were most closely related to H1N2 influenza viruses circulating in Danish swine. This virus had not previously been described in swine, mink or humans. PCRs assays specifically targeting the new reassortant were developed and used to screen influenza positive samples from humans and swine in Denmark with negative results. Thus, there was no evidence that this virus had spread to humans or was circulating in Danish pigs. In 2010 and 2011, influenza virus was again diagnosed in diseased mink in a few farms. The genetic typing showed that the virus was similar to the pandemic H1N1 virus circulating in humans and swine. The H3N2 virus was not detected in 2010 and 2011. Taken together, these findings indicate that mink is highly susceptible for influenza A virus of human and swine origin and may therefore act as a potential host/reservoir for influenza A viruses.
    Original languageEnglish
    Title of host publicationProceedings of the Xth International Scientific Congress in fur animal production : Scientifur volume 36 (3/4)
    PublisherWageningen Academic Publishers
    Publication date2012
    Pages153-156
    ISBN (Electronic)978-90-8686-760-8
    DOIs
    Publication statusPublished - 2012
    Event10th International Scientific Congress in fur animal production (IFASA 2012) - Copenhagen, Denmark
    Duration: 21 Aug 201224 Aug 2012
    http://www.ifasanet.org/index.php?option=com_content&view=article&id=28

    Conference

    Conference10th International Scientific Congress in fur animal production (IFASA 2012)
    CountryDenmark
    CityCopenhagen
    Period21/08/201224/08/2012
    Internet address

    Cite this

    Larsen, L. E., Breum, S. Ø., Trebbien, R., Bradstad, K., Nielsen, L. P., Chriél, M., Jensen, T. H., Hjulsager, C. K., Handberg, K., Jørgensen, P. H., Harslund, J. L. F., Rangstrup-Christensen, L., Petersen, B., & Hammer , A. S. (2012). Outbreaks of influenza A virus in farmed mink (Neovison vison) in Denmark: molecular characterization of the viruses. In Proceedings of the Xth International Scientific Congress in fur animal production: Scientifur volume 36 (3/4) (pp. 153-156). Wageningen Academic Publishers. https://doi.org/10.3920/978-90-8686-760-8_21