Oscillatory connectivity as a diagnostic marker of dementia due to Alzheimer's disease

Christian Sandøe Musaeus*, Knut Engedal, Peter Høgh, Vesna Jelic, Morten Mørup, Mala Naik, Anne Rita Oeksengaard, Jon Snaedal, Lars Olof Wahlund, Gunhild Waldemar, Birgitte Bo Andersen

*Corresponding author for this work

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Abstract

Objective: Quantitative EEG power has not been as effective in discriminating between healthy aging and Alzheimer's disease as conventional biomarkers. But EEG coherence has shown promising results in small samples. The overall aim was to evaluate if EEG connectivity markers can discriminate between Alzheimer's disease, mild cognitive impairment, and healthy aging and to explore the early underlying changes in coherence. Methods: EEGs were included in the analysis from 135 healthy controls, 117 patients with mild cognitive impairment, and 117 patients with Alzheimer's disease from six Nordic memory clinics. Principal component analysis was performed before multinomial regression. Results: We found classification accuracies of above 95% based on coherence, imaginary part of coherence, and the weighted phase-lag index. The most prominent changes in coherence were decreased alpha coherence in Alzheimer's disease, which was correlated to the scores of the 10-word test in the Consortium to Establish a Registry for Alzheimer's Disease battery. Conclusions: The diagnostic accuracies for EEG connectivity measures are higher than findings from studies investigating EEG power and conventional Alzheimer's disease biomarkers. Furthermore, decreased alpha coherence is one of the earliest changes in Alzheimer's disease and associated with memory function. Significance: EEG connectivity measures may be useful supplementary diagnostic classifiers.

Original languageEnglish
JournalClinical Neurophysiology
Volume130
Issue number10
Pages (from-to)1889-1899
ISSN1388-2457
DOIs
Publication statusPublished - 1 Oct 2019

Keywords

  • Alzheimer's disease
  • Coherence
  • Diagnostic
  • EEG
  • Imaginary part of coherence
  • Mild cognitive impairment
  • Weighted phase-lag index

Cite this

Musaeus, C. S., Engedal, K., Høgh, P., Jelic, V., Mørup, M., Naik, M., ... Andersen, B. B. (2019). Oscillatory connectivity as a diagnostic marker of dementia due to Alzheimer's disease. Clinical Neurophysiology, 130(10), 1889-1899. https://doi.org/10.1016/j.clinph.2019.07.016
Musaeus, Christian Sandøe ; Engedal, Knut ; Høgh, Peter ; Jelic, Vesna ; Mørup, Morten ; Naik, Mala ; Oeksengaard, Anne Rita ; Snaedal, Jon ; Wahlund, Lars Olof ; Waldemar, Gunhild ; Andersen, Birgitte Bo. / Oscillatory connectivity as a diagnostic marker of dementia due to Alzheimer's disease. In: Clinical Neurophysiology. 2019 ; Vol. 130, No. 10. pp. 1889-1899.
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Musaeus, CS, Engedal, K, Høgh, P, Jelic, V, Mørup, M, Naik, M, Oeksengaard, AR, Snaedal, J, Wahlund, LO, Waldemar, G & Andersen, BB 2019, 'Oscillatory connectivity as a diagnostic marker of dementia due to Alzheimer's disease', Clinical Neurophysiology, vol. 130, no. 10, pp. 1889-1899. https://doi.org/10.1016/j.clinph.2019.07.016

Oscillatory connectivity as a diagnostic marker of dementia due to Alzheimer's disease. / Musaeus, Christian Sandøe; Engedal, Knut; Høgh, Peter; Jelic, Vesna; Mørup, Morten; Naik, Mala; Oeksengaard, Anne Rita; Snaedal, Jon; Wahlund, Lars Olof; Waldemar, Gunhild; Andersen, Birgitte Bo.

In: Clinical Neurophysiology, Vol. 130, No. 10, 01.10.2019, p. 1889-1899.

Research output: Contribution to journalJournal articleResearchpeer-review

TY - JOUR

T1 - Oscillatory connectivity as a diagnostic marker of dementia due to Alzheimer's disease

AU - Musaeus, Christian Sandøe

AU - Engedal, Knut

AU - Høgh, Peter

AU - Jelic, Vesna

AU - Mørup, Morten

AU - Naik, Mala

AU - Oeksengaard, Anne Rita

AU - Snaedal, Jon

AU - Wahlund, Lars Olof

AU - Waldemar, Gunhild

AU - Andersen, Birgitte Bo

PY - 2019/10/1

Y1 - 2019/10/1

N2 - Objective: Quantitative EEG power has not been as effective in discriminating between healthy aging and Alzheimer's disease as conventional biomarkers. But EEG coherence has shown promising results in small samples. The overall aim was to evaluate if EEG connectivity markers can discriminate between Alzheimer's disease, mild cognitive impairment, and healthy aging and to explore the early underlying changes in coherence. Methods: EEGs were included in the analysis from 135 healthy controls, 117 patients with mild cognitive impairment, and 117 patients with Alzheimer's disease from six Nordic memory clinics. Principal component analysis was performed before multinomial regression. Results: We found classification accuracies of above 95% based on coherence, imaginary part of coherence, and the weighted phase-lag index. The most prominent changes in coherence were decreased alpha coherence in Alzheimer's disease, which was correlated to the scores of the 10-word test in the Consortium to Establish a Registry for Alzheimer's Disease battery. Conclusions: The diagnostic accuracies for EEG connectivity measures are higher than findings from studies investigating EEG power and conventional Alzheimer's disease biomarkers. Furthermore, decreased alpha coherence is one of the earliest changes in Alzheimer's disease and associated with memory function. Significance: EEG connectivity measures may be useful supplementary diagnostic classifiers.

AB - Objective: Quantitative EEG power has not been as effective in discriminating between healthy aging and Alzheimer's disease as conventional biomarkers. But EEG coherence has shown promising results in small samples. The overall aim was to evaluate if EEG connectivity markers can discriminate between Alzheimer's disease, mild cognitive impairment, and healthy aging and to explore the early underlying changes in coherence. Methods: EEGs were included in the analysis from 135 healthy controls, 117 patients with mild cognitive impairment, and 117 patients with Alzheimer's disease from six Nordic memory clinics. Principal component analysis was performed before multinomial regression. Results: We found classification accuracies of above 95% based on coherence, imaginary part of coherence, and the weighted phase-lag index. The most prominent changes in coherence were decreased alpha coherence in Alzheimer's disease, which was correlated to the scores of the 10-word test in the Consortium to Establish a Registry for Alzheimer's Disease battery. Conclusions: The diagnostic accuracies for EEG connectivity measures are higher than findings from studies investigating EEG power and conventional Alzheimer's disease biomarkers. Furthermore, decreased alpha coherence is one of the earliest changes in Alzheimer's disease and associated with memory function. Significance: EEG connectivity measures may be useful supplementary diagnostic classifiers.

KW - Alzheimer's disease

KW - Coherence

KW - Diagnostic

KW - EEG

KW - Imaginary part of coherence

KW - Mild cognitive impairment

KW - Weighted phase-lag index

U2 - 10.1016/j.clinph.2019.07.016

DO - 10.1016/j.clinph.2019.07.016

M3 - Journal article

VL - 130

SP - 1889

EP - 1899

JO - Clinical Neurophysiology

JF - Clinical Neurophysiology

SN - 1388-2457

IS - 10

ER -