Order by disorder in plant signaling

Birthe Brandt Kragelund, Michael Krogh Jensen, Karen Skriver

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Protein intrinsic disorder (ID), referring to the lack of a fixed tertiary structure, is an emerging topic in plant science. Proteins with ID challenge our perception of protein interactions because of their malleable behavior. They are abundant in highly regulated processes such as cellular signaling and transcription, where they exploit the flexibility of ID. In this opinion article we highlight trends in the field of protein ID and discuss its implications for interactions between plant transcription factors (TFs) and the cellular signaling hub protein RADICAL-INDUCED CELL DEATH 1 (RCD1). We envision RCD1–TF interactions as models for translating knowledge of ID-based interactions in vitro to the organismal level in vivo, and urge increased focus on ID in basic plant research and agricultural sciences.
Original languageEnglish
JournalTrends in Plant Science
Issue number11
Pages (from-to)625-632
Publication statusPublished - 2012
Externally publishedYes


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