TY - JOUR
T1 - Orally ingestible medical devices for gut engineering
AU - Mandsberg, Nikolaj Kofoed
AU - Christfort, Juliane Fjelrad
AU - Kamguyan, Khorshid
AU - Boisen, Anja
AU - Srivastava, Sarvesh Kumar
PY - 2020
Y1 - 2020
N2 - Orally ingestible medical devices provide significant advancement for diagnosis and treatment of gastrointestinal (GI) tract-related conditions. From micro- to macroscale devices, with designs ranging from very simple to complex, these medical devices can be used for site-directed drug delivery in the GI tract, real-time imaging and sensing of gut biomarkers. Equipped with uni-direction release, or self-propulsion, or origami design, these microdevices are breaking the barriers associated with drug delivery, including biologics, across the GI tract. Further, on-board microelectronics allow imaging and sensing of gut tissue and biomarkers, providing a more comprehensive understanding of underlying pathophysiological conditions. We provide an overview of recent advances in orally ingestible medical devices towards drug delivery, imaging and sensing. Challenges associated with gut microenvironment, together with various activation/actuation modalities of medical devices for micromanipulation of the gut are discussed. We have critically examined the relationship between materials-device design-pharmacological responses with respect to existing regulatory guidelines and provided a clear roadmap for the future.
AB - Orally ingestible medical devices provide significant advancement for diagnosis and treatment of gastrointestinal (GI) tract-related conditions. From micro- to macroscale devices, with designs ranging from very simple to complex, these medical devices can be used for site-directed drug delivery in the GI tract, real-time imaging and sensing of gut biomarkers. Equipped with uni-direction release, or self-propulsion, or origami design, these microdevices are breaking the barriers associated with drug delivery, including biologics, across the GI tract. Further, on-board microelectronics allow imaging and sensing of gut tissue and biomarkers, providing a more comprehensive understanding of underlying pathophysiological conditions. We provide an overview of recent advances in orally ingestible medical devices towards drug delivery, imaging and sensing. Challenges associated with gut microenvironment, together with various activation/actuation modalities of medical devices for micromanipulation of the gut are discussed. We have critically examined the relationship between materials-device design-pharmacological responses with respect to existing regulatory guidelines and provided a clear roadmap for the future.
KW - Medical microdevices
KW - Gastrointestinal tract
KW - Gut microbiota
KW - Oral drug delivery
KW - GI diagnostics
U2 - 10.1016/j.addr.2020.05.004
DO - 10.1016/j.addr.2020.05.004
M3 - Journal article
C2 - 32416112
SN - 0169-409X
VL - 165-166
SP - 142
EP - 154
JO - Advanced Drug Delivery Reviews
JF - Advanced Drug Delivery Reviews
ER -