Oral administration of melatonin counteracts several of the effects of chronic stress in rainbow trout

M. Conde-Sieira, J. L. P. Munoz, M. A. Lopez-Patino, Manuel Gesto, J. L. Soengas, J. M. Miguez

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

To assess a possible antistress role of melatonin in fish, we orally administered melatonin to rainbow trout for 10 d and then kept the fish under normal or high stocking density conditions during the last 4 d. Food intake; biochemical parameters in plasma (cortisol, glucose, and lactate concentrations); liver (glucose and glycogen concentrations, and glycogen synthase activity); enzyme activities of amylase, lipase, and protease in foregut and midgut; and content of the hypothalamic neurotransmitters dopamine and serotonin, as well as their oxidized metabolites, 3,4-dihydroxyphenylacetic acid and 5-hydroxy-3-indoleacetic acid, were evaluated under those conditions. High stocking density conditions alone induced changes indicative of stress conditions in plasma cortisol concentrations, liver glycogenolytic potential, the activities of some digestive enzymes, and the 3,4-dihydroxyphenylacetic acid-to-dopamine and 5-hydroxy-3-indoleacetic acid-to-serotonin ratios in the hypothalamus. Melatonin treatment in nonstressed fish induced an increase in liver glycogenolytic potential, increased the activity of some digestive enzymes, and enhanced serotoninergic and dopaminergic metabolism in hypothalamus. The presence of melatonin in stressed fish resulted in a significant interaction with cortisol concentrations in plasma, glycogen content, and glycogen synthase activity in liver and dopaminergic and serotoninergic metabolism in the hypothalamus. In general, the presence of melatonin mitigated several of the effects induced by stress, supporting an antistress role for melatonin in rainbow trout. (C) 2014 Elsevier Inc. All rights reserved.
Original languageEnglish
JournalDomestic Animal Endocrinology
Volume46
Issue number1
Pages (from-to)26-36
ISSN0739-7240
DOIs
Publication statusPublished - 2014
Externally publishedYes

Keywords

  • AGRICULTURE,
  • ENDOCRINOLOGY
  • CORTICOTROPIN-RELEASING-FACTOR
  • BRAIN MONOAMINERGIC ACTIVITY
  • GOLDFISH CARASSIUS-AURATUS
  • BASS DICENTRARCHUS-LABRAX
  • SOLE SOLEA-SENEGALENSIS
  • PLASMA-CORTISOL LEVELS
  • FOOD-INTAKE
  • ONCORHYNCHUS-MYKISS
  • GLUCOSENSING CAPACITY
  • FEEDING-BEHAVIOR
  • Trout
  • Melatonin
  • Stress
  • Food intake
  • Cortisol
  • Brain neurotransmitters
  • Animal Science and Zoology
  • Endocrinology
  • Food Animals
  • Medicine (all)
  • amylase
  • dopamine
  • glucose blood level
  • glycogen
  • hydrocortisone
  • lactic acid
  • melatonin
  • peptide hydrolase
  • serotonin
  • triacylglycerol lipase
  • animal
  • blood
  • drug effects
  • eating
  • enzymology
  • female
  • hypothalamus
  • liver
  • metabolism
  • physiological stress
  • physiology
  • rainbow trout
  • Amylases
  • Animals
  • Blood Glucose
  • Dopamine
  • Eating
  • Female
  • Glycogen
  • Hydrocortisone
  • Hypothalamus
  • Lactic Acid
  • Lipase
  • Liver
  • Oncorhynchus mykiss
  • Peptide Hydrolases
  • Serotonin
  • Stress, Physiological
  • antistress role
  • biochemical parameter
  • chronic stress
  • dopaminergic metabolism
  • enzyme activity
  • food intake
  • glycogenolytic potential
  • high stocking density condition
  • neuroendocrine parameter
  • serotoninergic metabolism
  • stress response
  • Pisces Vertebrata Chordata Animalia (Animals, Chordates, Fish, Nonhuman Vertebrates, Vertebrates) - Osteichthyes [85206] Oncorhynchus mykiss species rainbow trout common commercial species female
  • 3,4-dihydroxyphenylacetic acid oxidized metabolite
  • 5-hydroxy-3-indoleacetic acid 54-16-0 oxidized metabolite
  • amylase 9000-92-4
  • cortisol 50-23-7
  • digestive enzyme
  • dopamine 51-61-6 hypothalamic neurotransmitter
  • glucose 58367-01-4
  • glycogen 9005-79-2
  • glycogen synthase 37338-93-5 EC 2.4.1.21
  • lactate 113-21-3
  • lipase 9001-62-1 EC 3.1.1.3
  • melatonin 73-31-4 hormone-drug dietary supplement dosage, oral administration
  • protease 9001-92-7 EC 3.4.21.7
  • serotonin 50-67-9 hypothalamic neurotransmitter
  • 07516, Ecology: environmental biology - Wildlife management: aquatic
  • 10060, Biochemistry studies - General
  • 10064, Biochemistry studies - Proteins, peptides and amino acids
  • 10067, Biochemistry studies - Sterols and steroids
  • 10068, Biochemistry studies - Carbohydrates
  • 10802, Enzymes - General and comparative studies: coenzymes
  • 12512, Pathology - Therapy
  • 14004, Digestive system - Physiology and biochemistry
  • 15002, Blood - Blood and lymph studies
  • 15004, Blood - Blood cell studies
  • 17002, Endocrine - General
  • 17020, Endocrine - Neuroendocrinology
  • 20504, Nervous system - Physiology and biochemistry
  • 22002, Pharmacology - General
  • 22016, Pharmacology - Endocrine system
  • Chemical Coordination and Homeostasis
  • Neural Coordination
  • foregut digestive system
  • hypothalamus nervous system
  • liver digestive system
  • midgut digestive system
  • plasma blood and lymphatics
  • Aquaculture
  • Biochemistry and Molecular Biophysics
  • Endocrine System
  • Nervous System
  • Pharmacology

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