Optomagnetic studies of ph-switchable nanoparticle agglutination via triplex dna formation

Gabriel Khose Antonio Minero, Jeppe Fock, J.S. McCaskill, Mikkel Fougt Hansen

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    Abstract

    Polypurine-polypyrimidine sequences found in eukaryotic genomes can fold into a triple-helical structure if the sequences exhibit mirror symmetry [1]. They have been shown to stop DNA replication in vitro and in cell cultures and play a significant role in genetic regulation. New methods are needed to investigate switching behavior of triplex DNA complexes under controlled conditions.
    Original languageEnglish
    Title of host publicationProceedings of Microtas 2016
    Number of pages2
    Publication date2016
    Publication statusPublished - 2016
    Event20th International Conference on Miniaturized Systems for Chemistry and Life Sciences: MicroTAS 2016 - Dublin, Ireland
    Duration: 9 Oct 201613 Oct 2016
    Conference number: 20
    http://www.microtas2016.org/

    Conference

    Conference20th International Conference on Miniaturized Systems for Chemistry and Life Sciences
    Number20
    CountryIreland
    CityDublin
    Period09/10/201613/10/2016
    Internet address

    Keywords

    • DNA triplex
    • Nanaoparticle
    • Biosensor
    • pH

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