Abstract
Dissolution dynamic nuclear polarization (dDNP) has permitted the production of highly polarized liquid-state samples enabling real-time imaging of metabolic processes non-invasively in vivo. The desire for higher magnetic resonance sensitivity has led to the development of multiple home-built and commercial dDNP polarizers employing solid-state microwave sources. Providing efficient microwave delivery that avoids unwanted heating of the sample is a crucial step to achieve high nuclear polarization. Consequently, a process is described to reduce waveguide attenuation due to resistive loss thereby doubling the delivered power. A mirror and reflector are designed and tested to increase the microwave field density across the sample volume resulting in a 2.3 dB increase of delivered power. Thermal considerations with regards to waveguide geometry and dDNP probe design are discussed. A thermal model of the dDNP probe is computed and experimentally verified.
Original language | English |
---|---|
Journal | Journal of Magnetic Resonance |
Volume | 305 |
Pages (from-to) | 58-65 |
Number of pages | 8 |
ISSN | 1090-7807 |
DOIs | |
Publication status | Published - 2019 |
Keywords
- Disssolution-DNP
- Microwave
- Electromagnetic simulation
- Solid-state NMR