Optimized microwave delivery in dDNP

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

Dissolution dynamic nuclear polarization (dDNP) has permitted the production of highly polarized liquid-state samples enabling real-time imaging of metabolic processes non-invasively in vivo. The desire for higher magnetic resonance sensitivity has led to the development of multiple home-built and commercial dDNP polarizers employing solid-state microwave sources. Providing efficient microwave delivery that avoids unwanted heating of the sample is a crucial step to achieve high nuclear polarization. Consequently, a process is described to reduce waveguide attenuation due to resistive loss thereby doubling the delivered power. A mirror and reflector are designed and tested to increase the microwave field density across the sample volume resulting in a 2.3 dB increase of delivered power. Thermal considerations with regards to waveguide geometry and dDNP probe design are discussed. A thermal model of the dDNP probe is computed and experimentally verified.
Original languageEnglish
JournalJournal of Magnetic Resonance
Volume305
Pages (from-to)58-65
Number of pages8
ISSN1090-7807
DOIs
Publication statusPublished - 2019

Keywords

  • Disssolution-DNP
  • Microwave
  • Electromagnetic simulation
  • Solid-state NMR

Cite this

@article{1be9d662f7954919b55b8568ec2dab36,
title = "Optimized microwave delivery in dDNP",
abstract = "Dissolution dynamic nuclear polarization (dDNP) has permitted the production of highly polarized liquid-state samples enabling real-time imaging of metabolic processes non-invasively in vivo. The desire for higher magnetic resonance sensitivity has led to the development of multiple home-built and commercial dDNP polarizers employing solid-state microwave sources. Providing efficient microwave delivery that avoids unwanted heating of the sample is a crucial step to achieve high nuclear polarization. Consequently, a process is described to reduce waveguide attenuation due to resistive loss thereby doubling the delivered power. A mirror and reflector are designed and tested to increase the microwave field density across the sample volume resulting in a 2.3 dB increase of delivered power. Thermal considerations with regards to waveguide geometry and dDNP probe design are discussed. A thermal model of the dDNP probe is computed and experimentally verified.",
keywords = "Disssolution-DNP, Microwave, Electromagnetic simulation, Solid-state NMR",
author = "Albannay, {Mohammed M.} and {M.O. Vinther}, Joachim and Andrea Capozzi and Vitaliy Zhurbenko and Ardenkj{\ae}r-Larsen, {Jan Henrik}",
year = "2019",
doi = "10.1016/j.jmr.2019.06.004",
language = "English",
volume = "305",
pages = "58--65",
journal = "Journal of Magnetic Resonance",
issn = "1090-7807",
publisher = "Elsevier",

}

Optimized microwave delivery in dDNP. / Albannay, Mohammed M.; M.O. Vinther, Joachim; Capozzi, Andrea; Zhurbenko, Vitaliy; Ardenkjær-Larsen, Jan Henrik.

In: Journal of Magnetic Resonance, Vol. 305, 2019, p. 58-65.

Research output: Contribution to journalJournal articleResearchpeer-review

TY - JOUR

T1 - Optimized microwave delivery in dDNP

AU - Albannay, Mohammed M.

AU - M.O. Vinther, Joachim

AU - Capozzi, Andrea

AU - Zhurbenko, Vitaliy

AU - Ardenkjær-Larsen, Jan Henrik

PY - 2019

Y1 - 2019

N2 - Dissolution dynamic nuclear polarization (dDNP) has permitted the production of highly polarized liquid-state samples enabling real-time imaging of metabolic processes non-invasively in vivo. The desire for higher magnetic resonance sensitivity has led to the development of multiple home-built and commercial dDNP polarizers employing solid-state microwave sources. Providing efficient microwave delivery that avoids unwanted heating of the sample is a crucial step to achieve high nuclear polarization. Consequently, a process is described to reduce waveguide attenuation due to resistive loss thereby doubling the delivered power. A mirror and reflector are designed and tested to increase the microwave field density across the sample volume resulting in a 2.3 dB increase of delivered power. Thermal considerations with regards to waveguide geometry and dDNP probe design are discussed. A thermal model of the dDNP probe is computed and experimentally verified.

AB - Dissolution dynamic nuclear polarization (dDNP) has permitted the production of highly polarized liquid-state samples enabling real-time imaging of metabolic processes non-invasively in vivo. The desire for higher magnetic resonance sensitivity has led to the development of multiple home-built and commercial dDNP polarizers employing solid-state microwave sources. Providing efficient microwave delivery that avoids unwanted heating of the sample is a crucial step to achieve high nuclear polarization. Consequently, a process is described to reduce waveguide attenuation due to resistive loss thereby doubling the delivered power. A mirror and reflector are designed and tested to increase the microwave field density across the sample volume resulting in a 2.3 dB increase of delivered power. Thermal considerations with regards to waveguide geometry and dDNP probe design are discussed. A thermal model of the dDNP probe is computed and experimentally verified.

KW - Disssolution-DNP

KW - Microwave

KW - Electromagnetic simulation

KW - Solid-state NMR

U2 - 10.1016/j.jmr.2019.06.004

DO - 10.1016/j.jmr.2019.06.004

M3 - Journal article

VL - 305

SP - 58

EP - 65

JO - Journal of Magnetic Resonance

JF - Journal of Magnetic Resonance

SN - 1090-7807

ER -