Optimized microbial cells for production of melatonin and other compounds

Hao Luo (Inventor), Jochen Förster (Inventor)

Research output: Patent

236 Downloads (Pure)


Described herein are recombinant microbial host cells comprising biosynthetic pathways and their use in producing oxidation products and downstream products, e.g., melatonin and related compounds, as well as enzyme variants, nucleic acids, vectors and methods useful for preparing and using such cells. In specific aspects, the present invention relates to monooxygenases, e.g., amino acid hydroxylases, with a modified cofactor-dependency, and to enzyme variants and microbial cells providing for an improved supply of cofactors.

Original languageEnglish
IPCC12P 17/ 10 A I
Patent numberWO2017167866
Filing date05/10/2017
Country/TerritoryInternational Bureau of the World Intellectual Property Organization (WIPO)
Priority date19/05/2016
Priority numberEP20160170405
Publication statusPublished - 5 Oct 2017


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